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feoB Fe(2(+)) transporter FeoB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947919, updated on 26-Mar-2025

Summary

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Official Symbol
feoB
Official Full Name
Fe(2(+)) transporter FeoB
Primary source
ECOCYC:EG12102
Locus tag
b3409
See related
ASAP:ABE-0011126
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3396
Summary
FeoB GTPase actvity is required for ferrous iron uptake; it slowly hydrolyzes its bound GTP. [More information is available at EcoGene: EG12102]. FeoB is a ferrous iron uptake system belonging to the Ferrous Iron Uptake (FeoB) transporter family . [More information is available at EcoCyc: EG12102].
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Genomic context

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Sequence:
NC_000913.3 (3540407..3542728)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative RNA-binding protein YhgF Neighboring gene ferrous iron transport protein A Neighboring gene ferrous iron transport protein FeoC Neighboring gene recombination-promoting nuclease RpnA Neighboring gene pimeloyl-acyl carrier protein methyl ester esterase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exploring the correlation between the sequence composition of the nucleotide binding G5 loop of the FeoB GTPase domain (NFeoB) and intrinsic rate of GDP release. Guilfoyle AP, et al. Biosci Rep, 2014 Dec 12. PMID 25374115, Free PMC Article
  2. Structural basis of GDP release and gating in G protein coupled Fe2+ transport. Guilfoyle A, et al. EMBO J, 2009 Sep 2. PMID 19629046, Free PMC Article
  3. Escherichia coli K-12 ferrous iron uptake mutants are impaired in their ability to colonize the mouse intestine. Stojiljkovic I, et al. FEMS Microbiol Lett, 1993 Mar 15. PMID 8472918
  4. Bacterial iron homeostasis. Andrews SC, et al. FEMS Microbiol Rev, 2003 Jun. PMID 12829269
  5. Iron transport in Escherichia coli: all has not been said and done. Grass G. Biometals, 2006 Apr. PMID 16718601

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that several of the residues in the G5 loop of the FeoB GTPase domain have an important role in the intrinsic affinity and release of GDP.
    Title: Exploring the correlation between the sequence composition of the nucleotide binding G5 loop of the FeoB GTPase domain (NFeoB) and intrinsic rate of GDP release.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables GTP binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrous iron transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within iron ion import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within iron ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Fe(2(+)) transporter FeoB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3540407..3542728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417868.1 Fe(2(+)) transporter FeoB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417868.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377D8V8, A0A8S7TAD7
    Conserved Domains (1) summary
    PRK09554
    Location:1 → 773
    feoB; Fe(2+) transporter permease subunit FeoB
Nucleotide Protein
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