U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ompR DNA-binding transcriptional dual regulator OmpR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947913, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
ompR
Gene description
DNA-binding transcriptional dual regulator OmpR
Primary source
ASAP:ABE-0011110
Locus tag
b3405
See related
ECOCYC:EG10672
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cry; ECK3392; kmt; ompB
Summary
The cognate sensor kinase for OmpR is EnvZ. [More information is available at EcoGene: EG10672].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (3535865..3536584, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transport protein YhgE Neighboring gene phosphoenolpyruvate carboxykinase (ATP) Neighboring gene sensor histidine kinase EnvZ Neighboring gene transcription elongation factor GreB Neighboring gene putative RNA-binding protein YhgF

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. OmpR coordinates the expression of virulence factors of Enterohemorrhagic Escherichia coli in the alimentary tract of Caenorhabditis elegans. Wang ST, et al. Mol Microbiol, 2021 Jul. PMID 33567149
  2. Structural Alteration of OmpR as a Source of Ertapenem Resistance in a CTX-M-15-Producing Escherichia coli O25b:H4 Sequence Type 131 Clinical Isolate. Dupont H, et al. Antimicrob Agents Chemother, 2017 May. PMID 28264855, Free PMC Article
  3. Single cell super-resolution imaging of E. coli OmpR during environmental stress. Foo YH, et al. Integr Biol (Camb), 2015 Oct. PMID 26156621, Free PMC Article
  4. Bacterial regulon evolution: distinct responses and roles for the identical OmpR proteins of Salmonella Typhimurium and Escherichia coli in the acid stress response. Quinn HJ, et al. PLoS Genet, 2014 Mar. PMID 24603618, Free PMC Article
  5. Survival of uropathogenic Escherichia coli in the murine urinary tract is dependent on OmpR. Schwan WR. Microbiology (Reading), 2009 Jun. PMID 19383700, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OmpR coordinates the expression of virulence factors of Enterohemorrhagic Escherichia coli in the alimentary tract of Caenorhabditis elegans.
    Title: OmpR coordinates the expression of virulence factors of Enterohemorrhagic Escherichia coli in the alimentary tract of Caenorhabditis elegans.
  2. Roles of the EnvZ/OmpR Two-Component System and Porins in Iron Acquisition in Escherichia coli.
    Title: Roles of the EnvZ/OmpR Two-Component System and Porins in Iron Acquisition in Escherichia coli.
  3. Reduced expression of the porin master regulator OmpR and its cognate kinase EnvZ is used as a resistance strategy by E. coli cells to survive ammonia-mediated antibiosis.
    Title: Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species.
  4. findings reveal an unknown OmpC-dependent mechanism of ethanol tolerance in a manner of EnvZ/OmpR regulation.
    Title: Identification of ethanol tolerant outer membrane proteome reveals OmpC-dependent mechanism in a manner of EnvZ/OmpR regulation in Escherichia coli.
  5. During osmotic stress, the internal pH is above the threshold, triggering distinct osmolarity response regulator proteins (OmpR)-related pathways.
    Title: Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells.
  6. Influence of csgD and ompR on Nanomechanics, Adhesion Forces, and Curli Properties of E. coli.
    Title: Influence of csgD and ompR on Nanomechanics, Adhesion Forces, and Curli Properties of E. coli.
  7. This report demonstrates for the first time that ertapenem resistance may emerge clinically from ESBL-producing E. coli due to mutations that modulate the OmpR activity.
    Title: Structural Alteration of OmpR as a Source of Ertapenem Resistance in a CTX-M-15-Producing Escherichia coli O25b:H4 Sequence Type 131 Clinical Isolate.
  8. under acidic conditions, we observed evidence of a spatial correlation between the DNA and the inner membrane, suggesting a mechanical link through an active DNA-OmpR-EnvZ complex
    Title: Single cell super-resolution imaging of E. coli OmpR during environmental stress.
  9. ability of OmpR to recruit additional genes to its regulon arises from its modest requirements for specificity in its DNA targets with its preference for relaxed DNA allowing it to cooperate with DNA-topology-based allostery to modulate transcription
    Title: Bacterial regulon evolution: distinct responses and roles for the identical OmpR proteins of Salmonella Typhimurium and Escherichia coli in the acid stress response.
  10. Together these results suggest that OmpR regulates fimB in uropathogenic Escherichia coli and may be post-transcriptionally regulated in a low pH/high osmolality environment.
    Title: OmpR regulation of the uropathogenic Escherichia coli fimB gene in an acidic/high osmolality environment.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay response regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorelay response regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorelay signal transduction system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DNA-binding transcriptional dual regulator OmpR

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3535865..3536584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417864.1 DNA-binding transcriptional dual regulator OmpR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417864.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AGX4, A0A831GJT8
    Conserved Domains (1) summary
    PRK09468
    Location:1 → 238
    ompR; osmolarity response regulator; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.