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rpe ribulose-phosphate 3-epimerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947896, updated on 30-Jul-2025
Official Symbol
rpe
Official Full Name
ribulose-phosphate 3-epimerase
Primary source
ECOCYC:M004
Locus tag
b3386
See related
ASAP:ABE-0011061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dod; ECK3373; yhfD
Summary
Ribulose phosphate 3-epimerase is an enzyme of the non-oxidative branch of the pentose phosphate pathway. [More information is available at EcoCyc: M004].
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Sequence:
NC_000913.3 (3514382..3515059, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative DNA-binding transcriptional regulator YhfZ Neighboring gene tryptophan--tRNA ligase Neighboring gene phosphoglycolate phosphatase Neighboring gene DNA adenine methyltransferase Neighboring gene cell division protein DamX

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Impaired growth of an Escherichia coli rpe mutant lacking ribulose-5-phosphate epimerase activity. Lyngstadaas A, et al. Biochim Biophys Acta, 1998 Aug 24. PMID 9729441
  2. Involvement of the ribulosephosphate epimerase gene in the dnaA and dnaR functions for initiation of chromosome replication in Escherichia coli. Sakakibara Y. Mol Microbiol, 1997 May. PMID 9194706
  3. Effects of edd and pgi disruptions on inosine accumulation in Escherichia coli. Shimaoka M, et al. Biosci Biotechnol Biochem, 2005 Jul. PMID 16041126
  4. Genetics of pentose-phosphate pathway enzymes of Escherichia coli K-12. Sprenger GA. Arch Microbiol, 1995 Nov. PMID 8572885
  5. Characterization of three genes in the dam-containing operon of Escherichia coli. Lyngstadaas A, et al. Mol Gen Genet, 1995 Jun 10. PMID 7603433

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables D-ribulose-phosphate 3-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-ribulose-phosphate 3-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-ribulose-phosphate 3-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables D-ribulose-phosphate 3-epimerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables racemase and epimerase activity, acting on carbohydrates and derivatives IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pentose catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pentose-phosphate shunt, non-oxidative branch EXP
Inferred from Experiment
more info
 PubMed 
involved_in pentose-phosphate shunt, non-oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
ribulose-phosphate 3-epimerase
NP_417845.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3514382..3515059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417845.1 ribulose-phosphate 3-epimerase

    See identical proteins and their annotated locations for NP_417845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9APR2
    Conserved Domains (1) summary
    cl21457
    Location:5 → 222
    TIM; TIM-like beta/alpha barrel domains
Nucleotide Protein
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