trpS tryptophan--tRNA ligase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: trpS
Official Full Name: tryptophan--tRNA ligase
Primary source: ECOCYC:EG11030
Locus tag: b3384
See related: ASAP:ABE-0011056
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3371
Summary: Tryptophanyl-tRNA synthetase (TrpRS) is a member of the family of aminoacyl-tRNA synthetases, which interpret the genetic code by covalently linking amino acids to their specific tRNA molecules. [More information is available at EcoCyc: EG11030].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
Title: An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
N-terminus verified by Edman degradation on mature peptide
Title: Sequence homologies between the tryptophanyl tRNA synthetases of Bacillus stearothermophilus and Escherichia coli.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables tryptophan-tRNA ligase activity	EXP Inferred from Experiment more info	PubMed
enables tryptophan-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables tryptophan-tRNA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in tryptophanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tryptophanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tryptophanyl-tRNA aminoacylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	EXP Inferred from Experiment more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed