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nirD nitrite reductase (NADH) small subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947881, updated on 6-Jul-2026
Official Symbol
nirD
Official Full Name
nitrite reductase (NADH) small subunit
Primary source
ECOCYC:EG10655
Locus tag
b3366
See related
ASAP:ABE-0011005
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3354
Summary
The nirD gene encodes the small subunit of the nitrite reductase. [More information is available at EcoCyc: EG10655].
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Sequence:
NC_000913.3 (3496551..3496877)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase A Neighboring gene putative transporter TsgA Neighboring gene nitrite reductase (NADH) large subunit Neighboring gene nitrite transporter NirC Neighboring gene siroheme synthase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Electron-spin-resonance studies of the NADH-dependent nitrite reductase from Escherichia coli K12. Cammack R, et al. Biochem J, 1982 Nov 1. PMID 6297458, Free PMC Article
  2. Purification and properties of nitrite reductase from Escherichia coli K12. Coleman KJ, et al. Biochem J, 1978 Nov 1. PMID 217342, Free PMC Article
  3. The steady-state kinetics of the NADH-dependent nitrite reductase from Escherichia coli K 12. Nitrite and hydroxylamine reduction. Jackson RH, et al. Biochem J, 1981 Oct 1. PMID 6279095, Free PMC Article
  4. Clustering as a Means To Control Nitrate Respiration Efficiency and Toxicity in Escherichia coli. Bulot S, et al. mBio, 2019 Oct 22. PMID 31641084, Free PMC Article
  5. Suppression of FNR-dependent transcription activation at the Escherichia coli nir promoter by Fis, IHF and H-NS: modulation of transcription initiation by a complex nucleo-protein assembly. Browning DF, et al. Mol Microbiol, 2000 Sep. PMID 10972841

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli.
    Title: NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to nitrite reductase (NADH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nitrite reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to nitrite reductase (NADH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nitrite reductase [NAD(P)H] activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of nitrite reductase complex [NAD(P)H] IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nitrite reductase complex [NAD(P)H] IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
nitrite reductase (NADH) small subunit
NP_417825.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3496551..3496877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417825.1 nitrite reductase (NADH) small subunit

    See identical proteins and their annotated locations for NP_417825.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK09511
    Location:1 → 108
    nirD; nitrite reductase small subunit NirD
Nucleotide Protein
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