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ppiA peptidyl-prolyl cis-trans isomerase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947870, updated on 26-Mar-2025
Official Symbol
ppiA
Official Full Name
peptidyl-prolyl cis-trans isomerase A
Primary source
ECOCYC:EG10757
Locus tag
b3363
See related
ASAP:ABE-0010992
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3351; rot; rotA
Summary
An fkpA, surA, ppiB, ppiD quadruple mutant is viable. [More information is available at EcoGene: EG10757]. PpiA is a peptidyl-prolyl cis-trans-isomerase (PPIase), catalyzing the conformational isomerization of prolyl residues in peptides. [More information is available at EcoCyc: EG10757].
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Sequence:
NC_000913.3 (3491725..3492297, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene aminodeoxychorismate synthase subunit 2 Neighboring gene putative adenosine monophosphate--protein transferase Fic Neighboring gene DUF2559 domain-containing protein YhfG Neighboring gene putative transporter TsgA Neighboring gene nitrite reductase (NADH) large subunit Neighboring gene nitrite reductase (NADH) small subunit

Genomic Sequence:
NC_000913.3

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
PubMed 
located_in periplasmic space IDA
Inferred from Direct Assay
more info
PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
peptidyl-prolyl cis-trans isomerase A
NP_417822.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3491725..3492297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417822.1 peptidyl-prolyl cis-trans isomerase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417822.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376JR54, A0AAN3H6V2
    Conserved Domains (1) summary
    PRK10903
    Location:1190
    PRK10903; peptidylprolyl isomerase A