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crp DNA-binding transcriptional dual regulator CRP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947867, updated on 25-Jun-2025
Official Symbol
crp
Official Full Name
DNA-binding transcriptional dual regulator CRP
Primary source
ECOCYC:EG10164
Locus tag
b3357
See related
ASAP:ABE-0010970
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cap; csm; ECK3345; gurB
Summary
[More information is available at EcoCyc: EG10164].
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Sequence:
NC_000913.3 (3486120..3486752)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phosphoribulokinase Neighboring gene OsmC family protein YhfA Neighboring gene putative transporter YhfK Neighboring gene N-acetylornithine aminotransferase/N-succinyldiaminopimelate aminotransferase Neighboring gene protein YrfJ

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. In vitro interaction of the Escherichia coli cyclic AMP receptor protein with the lactose repressor. Fried MG, et al. J Biol Chem, 2001 Apr 6. PMID 11152685
  2. Linkage of multiequilibria in DNA recognition by the D53H Escherichia coli cAMP receptor protein. Lin SH, et al. Biochemistry, 2002 Dec 17. PMID 12475242
  3. Structure and dynamics of the modular halves of Escherichia coli cyclic AMP receptor protein. Li J, et al. Biochemistry, 2002 Dec 17. PMID 12475225
  4. [Functional interrelationship between elements of the Escherichia coli udp gene promotor responsible for binding regulatory proteins CytR, CRP, and RNA polymerase]. Zolotukhina MA, et al. Genetika, 2002 Sep. PMID 12391883
  5. Catabolite repression of Escherichia coli biofilm formation. Jackson DW, et al. J Bacteriol, 2002 Jun. PMID 12029060, Free PMC Article

See all (319) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of Aerobic Succinate Transporter dctA of E. coli by cAMP-CRP, DcuS-DcuR, and EIIAGlc: Succinate as a Carbon Substrate and Signaling Molecule.
    Title: Regulation of Aerobic Succinate Transporter dctA of E. coli by cAMP-CRP, DcuS-DcuR, and EIIAGlc: Succinate as a Carbon Substrate and Signaling Molecule.
  2. Restoring Global Gene Regulation through Experimental Evolution Uncovers a NAP (Nucleoid-Associated Protein)-Like Behavior of Crp/Cap.
    Title: Restoring Global Gene Regulation through Experimental Evolution Uncovers a NAP (Nucleoid-Associated Protein)-Like Behavior of Crp/Cap.
  3. Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors.
    Title: Temporal evolution of master regulator Crp identifies pyrimidines as catabolite modulator factors.
  4. Glycine Cleavage System and cAMP Receptor Protein Co-Regulate CRISPR/cas3 Expression to Resist Bacteriophage.
    Title: Glycine Cleavage System and cAMP Receptor Protein Co-Regulate CRISPR/cas3 Expression to Resist Bacteriophage.
  5. The CRP subunits are energetically asymmetricand that mutations exert their effects differentially between the two subunits through networks of long-range communication.
    Title: Differential modulation of energy landscapes of cyclic AMP receptor protein (CRP) as a regulatory mechanism for class II CRP-dependent promoters.
  6. Hydrogen sulfide (H2S) is produced by Escherichia coli cells growing in a synthetic minimal medium containing thiosulfate as a sole inorganic sulfur source, but not in a medium only containing sulfate. E. coli generated H2S in a DNA-binding transcriptional dual regulator CRP-dependent manner as a response to glucose starvation.
    Title: Generation of hydrogen sulfide from sulfur assimilation in Escherichia coli.
  7. Escherichia coli deletion mutants lacking cAMP-receptor protein (CRP) maintains colony-forming activities even after a long period of starvation, while wild-type cells lost most of this activity. The lack of cAMP-CRP effectively retains high colony-forming activities, indicating that cAMP-CRP acts as a positive regulator necessary for the induction of the viable but non-culturable state in E. coli.
    Title: cAMP-CRP acts as a key regulator for the viable but non-culturable state in Escherichia coli.
  8. Data show that DNA-binding transcriptional dual regulators Cra and CRP are most active on poor carbon sources.
    Title: Systems assessment of transcriptional regulation on central carbon metabolism by Cra and CRP.
  9. Escherichia coli OxyS RNA triggers cephalothin resistance by modulating the expression of CRP-associated genes.
    Title: Escherichia coli OxyS RNA triggers cephalothin resistance by modulating the expression of CRP-associated genes.
  10. Study compares the ability of two statistical mechanical models of protein conformational change-to characterize the multi-step activation mechanism of the broadly acting CRP. These models have the predictive power to determine how combinations of mutations will interact, how double mutants will behave, and how each construct would regulate gene expression.
    Title: Theoretical analysis of inducer and operator binding for cyclic-AMP receptor protein mutants.
Submit: New GeneRIF Correction See all GeneRIFs (66)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
DNA-binding transcriptional dual regulator CRP

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3486120..3486752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417816.1 DNA-binding transcriptional dual regulator CRP [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417816.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AP45, A0A8S0FJE1
    Conserved Domains (1) summary
    PRK11753
    Location:1 → 210
    PRK11753; cAMP-activated global transcriptional regulator CRP
Nucleotide Protein
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