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fkpA peptidyl-prolyl cis-trans isomerase/OMP chaperone FkpA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947850, updated on 30-Jul-2025
Official Symbol
fkpA
Official Full Name
peptidyl-prolyl cis-trans isomerase/OMP chaperone FkpA
Primary source
ECOCYC:G7716
Locus tag
b3347
See related
ASAP:ABE-0010938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3334; yzzS
Summary
An fkpA, surA, ppiB, ppiD quadruple mutant is viable. [More information is available at EcoGene: EG12900]. FkpA is a heat shock peptidyl-prolyl isomerase (PPIase) which also has chaperone function. [More information is available at EcoCyc: G7716].
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Sequence:
NC_000913.3 (3476607..3477419, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene sulfurtransferase complex subunit TusC Neighboring gene sulfurtransferase complex subunit TusD Neighboring gene DNA-binding transcriptional regulator YheO Neighboring gene protein SlyX Neighboring gene FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Periplasmic chaperone FkpA is essential for imported colicin M toxicity. Hullmann J, et al. Mol Microbiol, 2008 Aug. PMID 18554332, Free PMC Article
  2. The periplasmic Escherichia coli peptidylprolyl cis,trans-isomerase FkpA. II. Isomerase-independent chaperone activity in vitro. Ramm K, et al. J Biol Chem, 2000 Jun 2. PMID 10748201
  3. Chaperone function of FkpA, a heat shock prolyl isomerase, in the periplasm of Escherichia coli. Arié JP, et al. Mol Microbiol, 2001 Jan. PMID 11123702
  4. Production of soluble and functional engineered antibodies in Escherichia coli improved by FkpA. Zhang Z, et al. Biotechniques, 2003 Nov. PMID 14628677
  5. Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins. Horne SM, et al. Arch Microbiol, 1995 May. PMID 7540828

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phage HK97 genome injection requires the activities of the inner membrane glucose transporter protein, PtsG, and the periplasmic chaperone, FkpA and requirements for PtsG and FkpA are determined by the sequence of the phage tape measure protein.
    Title: The phage tail tape measure protein, an inner membrane protein and a periplasmic chaperone play connected roles in the genome injection process of E. coli phage HK97.
  2. FkpA specifically assists in folding colicin M into an active toxin in the periplasm and PPIase is essential for colicin M activity.
    Title: Periplasmic chaperone FkpA is essential for imported colicin M toxicity.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: '98 Escherichia coli SWISS-2DPAGE database update.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein folding chaperone EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
peptidyl-prolyl cis-trans isomerase/OMP chaperone FkpA
NP_417806.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3476607..3477419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417806.1 peptidyl-prolyl cis-trans isomerase/OMP chaperone FkpA

    See identical proteins and their annotated locations for NP_417806.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1V2GC96, A0A377ACT4
    Conserved Domains (1) summary
    PRK10902
    Location:1 → 259
    PRK10902; FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
Nucleotide Protein
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