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gspO cryptic type II secretion system prepilin peptidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947840, updated on 3-Jun-2026
Official Symbol
gspO
Official Full Name
cryptic type II secretion system prepilin peptidase
Primary source
ECOCYC:EG11359
Locus tag
b3335
See related
ASAP:ABE-0010901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3322; hofD; hopD; hopO; yheC
Summary
GspG is processed by GspO when both are expressed. gspO complements a pulO mutation for pullanase secretion in a K-12 strain with the Klebsiella pul operon. [More information is available at EcoGene: EG11359]. In Escherichia coli, gspO is a member of an operon of genes (gspC-O) which are not normally expressed but are homologous to those encoding the secreton, or type II secretion machinery in Klebsiella oxytoca and Aeromonase hydrophila, among others . [More information is available at EcoCyc: EG11359].
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Sequence:
NC_000913.3 (3465543..3466220)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cryptic type II secretion system minor pseudopilin GspJ Neighboring gene cryptic type II secretion system minor pseudopilin GspK Neighboring gene cryptic type II secretion system protein GspL Neighboring gene cryptic type II secretion system protein GspM Neighboring gene bacterioferritin Neighboring gene bacterioferritin-associated ferredoxin

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterisation of a Pseudomonas aeruginosa twitching motility gene and evidence for a specialised protein export system widespread in eubacteria. Whitchurch CB, et al. Gene, 1991 May 15. PMID 1676385
  2. Cloning, sequencing, and mapping of the bacterioferritin gene (bfr) of Escherichia coli K-12. Andrews SC, et al. J Bacteriol, 1989 Jul. PMID 2661540, Free PMC Article
  3. Escherichia coli contains a set of genes homologous to those involved in protein secretion, DNA uptake and the assembly of type-4 fimbriae in other bacteria. Whitchurch CB, et al. Gene, 1994 Dec 2. PMID 7959070
  4. Protein secretion in Escherichia coli K-12: dead or alive? Pugsley AP, et al. Cell Mol Life Sci, 1998 Apr. PMID 9614971, Free PMC Article
  5. Type IV-like pili formed by the type II secreton: specificity, composition, bundling, polar localization, and surface presentation of peptides. Vignon G, et al. J Bacteriol, 2003 Jun. PMID 12754241, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables aspartic-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptidase activity EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
cryptic type II secretion system prepilin peptidase
NP_417794.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3465543..3466220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417794.1 cryptic type II secretion system prepilin peptidase

    See identical proteins and their annotated locations for NP_417794.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4C7AZY1
    Conserved Domains (1) summary
    COG1989
    Location:1 → 225
    PulO; Prepilin signal peptidase PulO (type II secretory pathway) or related peptidase [Cell motility, Intracellular trafficking, secretion, and vesicular transport]
Nucleotide Protein
Heading Accession and Version

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