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aroE shikimate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947776, updated on 25-Jun-2025
Official Symbol
aroE
Official Full Name
shikimate dehydrogenase
Primary source
ECOCYC:EG10077
Locus tag
b3281
See related
ASAP:ABE-0010763
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3268
Summary
Also called dehydroshikimate reductase. [More information is available at EcoGene: EG10077].
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Sequence:
NC_000913.3 (3430020..3430838, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S ribosomal RNA Neighboring gene hexapeptide repeat-containing protein YrdA Neighboring gene DUF1488 domain-containing protein YrdB Neighboring gene L-threonylcarbamoyladenylate synthase Neighboring gene putative DNA topoisomerase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass. Singh S, et al. Mol Biol Evol, 2008 Oct. PMID 18669580
  2. The purification of shikimate dehydrogenase from Escherichia coli. Chaudhuri S, et al. Biochem J, 1985 Feb 15. PMID 3883995, Free PMC Article
  3. The shikimate pathway : II. Stereospecificity of hydrogen transfer catalyzed by NADPH-dehydroshikimate reductase of E. coli. Dansette P, et al. Biochimie, 1974. PMID 4155957
  4. Comparative analysis of the QUTR transcription repressor protein and the three C-terminal domains of the pentafunctional AROM enzyme. Lamb HK, et al. Biochem J, 1996 Feb 1. PMID 8611179, Free PMC Article
  5. Pulse experiments as a prerequisite for the quantification of in vivo enzyme kinetics in aromatic amino acid pathway of Escherichia coli. Schmitz M, et al. Biotechnol Prog, 2002 Sep-Oct. PMID 12363343

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Sequencing and overexpression of the Escherichia coli aroE gene encoding shikimate dehydrogenase.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables shikimate 3-dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables shikimate 3-dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within aromatic amino acid family biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chorismate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chorismate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chorismate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in shikimate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in shikimate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
shikimate dehydrogenase
NP_417740.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3430020..3430838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417740.1 shikimate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417740.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    W1F5D2
    Conserved Domains (1) summary
    TIGR00507
    Location:2 → 271
    aroE; shikimate dehydrogenase
Nucleotide Protein
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