accC [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: accC
Primary source: ECOCYC:EG10276
Locus tag: b3256
See related: ASAP:ABE-0010677
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3243; fabG
Summary: Mutations result in negative cooperativity with respect to the substrate bicarbonate. [More information is available at EcoGene: EG10276]. Mutations in the homologous and functionally identical subunit in mammalian proprionyl-CoA carboxylase and 3-methylcrotonyl-CoA carboxylase result in the metabolic deficiency diseases of propionic acidemia or methylcrotonylglycinuria. [More information is available at EcoCyc: EG10276].
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Genomic context

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Sequence:: NC_000913.3 (3405917..3407266)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

For DnaK, acetyl-CoA carboxylase, biotin carboxylase subunit (AccC) and phosphate acetyltransferase (Pta) we also showed a direct role of PpiB in the functional control of these proteins because it increased the measured enzyme activity of each protein and further interfered with DnaK localization and the correct folding of AccC.
Title: Cyclophilin PpiB is involved in motility and biofilm formation via its functional association with certain proteins.
This study reports that increased levels of carboxyltransferase (CT) tetramer have no detectable effect on translation of the CT subunit mRNAs.
Title: Evidence against translational repression by the carboxyltransferase component of Escherichia coli acetyl coenzyme A carboxylase.
It was concluded that biotin carboxylase must be dimeric to fulfill its physiological function.
Title: Dimerization of the bacterial biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity in vivo.
analysis of biotin carboxylase in complex with substrates and implications for its catalytic mechanism
Title: Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism.
N-terminus verified by Edman degradation on complete protein
Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Results show that under AccC overexpression conditions AccB is underbiotinylated.
Title: Coordinate expression of the acetyl coenzyme A carboxylase genes, accB and accC, is necessary for normal regulation of biotin synthesis in Escherichia coli.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info
enables biotin carboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables biotin carboxylase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malonyl-CoA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in malonyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of acetyl-CoA carboxylase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: biotin carboxylase

NP_417722.1

EC 6.3.4.14

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

3405917..3407266

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_417722.1 biotin carboxylase [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_417722.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A418GHT7

Conserved Domains (1) summary

PRK08591
Location:1 → 449

PRK08591; acetyl-CoA carboxylase biotin carboxylase subunit; Validated