accB [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: accB
Primary source: ECOCYC:EG10275
Locus tag: b3255
See related: ASAP:ABE-0010675
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3242; fabE
Summary: AccB is biotinylated on K122 by BirA. [More information is available at EcoGene: EG10275]. The accB gene encodes the biotin carboxyl carrier protein (BCCP), a component of acetyl CoA carboxylase . [More information is available at EcoCyc: EG10275].
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NC_000913.3 Genomic Context describing neighboring genes

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N-terminus verified by Edman degradation on complete protein
Title: '98 Escherichia coli SWISS-2DPAGE database update.
These results indicate that either the environment of the physiological lysine residue or its intrinsic properties render it highly reactive to nonenzymatic biotinylation mediated by biotinoyl-5'-AMP.
Title: Nonenzymatic biotinylation of a biotin carboxyl carrier protein: unusual reactivity of the physiological target lysine.
Results show that under AccC overexpression conditions AccB is underbiotinylated.
Title: Coordinate expression of the acetyl coenzyme A carboxylase genes, accB and accC, is necessary for normal regulation of biotin synthesis in Escherichia coli.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables acetyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malonyl-CoA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of acetyl-CoA carboxylase complex	IDA Inferred from Direct Assay more info	PubMed
part_of acetyl-CoA carboxylase complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain