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nanQ N-acetylneuraminate anomerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947750, updated on 30-Jul-2025
Official Symbol
nanQ
Official Full Name
N-acetylneuraminate anomerase
Primary source
ECOCYC:G7675
Locus tag
b3221
See related
ASAP:ABE-0010569
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3210; yhcH
Summary
EbgC is a distant homolog of YiaL, YhcH and YjgK; all four match pfam PF04074. otherPDB (H. influenzae): [More information is available at EcoGene: EG12814]. yhcH may be part of the sialic acid catabolic operon, although it is not required for growth on N-acetylmannosamine . [More information is available at EcoCyc: G7675].
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Sequence:
NC_000913.3 (3369014..3369478, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DUF1120 domain-containing protein YhcF Neighboring gene DUF1016 domain-containing protein YhcG Neighboring gene N-acetylmannosamine kinase Neighboring gene putative N-acetylmannosamine-6-phosphate 2-epimerase Neighboring gene N-acetylneuraminate:H(+) symporter

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Complete nucleotide sequence of the E. coli N-acetylneuraminate lyase. Ohta Y, et al. Nucleic Acids Res, 1985 Dec 20. PMID 3909108, Free PMC Article
  2. Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli. Kalivoda KA, et al. J Bacteriol, 2003 Aug. PMID 12897000, Free PMC Article
  3. Diversity of microbial sialic acid metabolism. Vimr ER, et al. Microbiol Mol Biol Rev, 2004 Mar. PMID 15007099, Free PMC Article
  4. Identification and functional analysis of 'hypothetical' genes expressed in Haemophilus influenzae. Kolker E, et al. Nucleic Acids Res, 2004. PMID 15121896, Free PMC Article
  5. Crystal structure of the bacterial YhcH protein indicates a role in sialic acid catabolism. Teplyakov A, et al. J Bacteriol, 2005 Aug. PMID 16077096, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables racemase and epimerase activity, acting on carbohydrates and derivatives IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in N-acetylneuraminate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
N-acetylneuraminate anomerase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3369014..3369478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417688.1 N-acetylneuraminate anomerase

    See identical proteins and their annotated locations for NP_417688.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376D101, A0A8S7ED01, A0A8T5Y790
    Conserved Domains (1) summary
    TIGR00022
    Location:1 → 140
    TIGR00022; YhcH/YjgK/YiaL family protein
Nucleotide Protein
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