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nanT N-acetylneuraminate:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947740, updated on 30-Jul-2025
Official Symbol
nanT
Official Full Name
N-acetylneuraminate:H(+) symporter
Primary source
ECOCYC:G436
Locus tag
b3224
See related
ASAP:ABE-0010577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3213
Summary
Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG20145]. NanT is a probable sialic acid transporter. [More information is available at EcoCyc: G436].
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Sequence:
NC_000913.3 (3371084..3372574, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate anomerase Neighboring gene N-acetylmannosamine kinase Neighboring gene putative N-acetylmannosamine-6-phosphate 2-epimerase Neighboring gene N-acetylneuraminate lyase Neighboring gene DNA-binding transcriptional dual regulator NanR

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Uptake of N-acetylneuraminic acid by Escherichia coli K-235. Biochemical characterization of the transport system. Rodríguez-Aparicio LB, et al. Biochem J, 1987 Sep 1. PMID 2825630, Free PMC Article
  2. The sialic acid transporter NanT is necessary and sufficient for uptake of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) and its azido analog in Escherichia coli. Nilsson I, et al. Mol Microbiol, 2018 Oct. PMID 30076772
  3. Identification of an inducible catabolic system for sialic acids (nan) in Escherichia coli. Vimr ER, et al. J Bacteriol, 1985 Nov. PMID 3902799, Free PMC Article
  4. Derived structure of the putative sialic acid transporter from Escherichia coli predicts a novel sugar permease domain. Martinez J, et al. J Bacteriol, 1995 Oct. PMID 7592358, Free PMC Article
  5. Complete nucleotide sequence of the E. coli N-acetylneuraminate lyase. Ohta Y, et al. Nucleic Acids Res, 1985 Dec 20. PMID 3909108, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The sialic acid transporter NanT is the major E. coli 3-deoxy-d-manno-oct-2-ulosonic acid and its azido analog uptake mechanism.
    Title: The sialic acid transporter NanT is necessary and sufficient for uptake of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) and its azido analog in Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sialic acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sialic acid:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sialic acid:proton symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in carboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sialic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sialic acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
Preferred Names
N-acetylneuraminate:H(+) symporter

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3371084..3372574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417691.4 N-acetylneuraminate:H(+) symporter

    See identical proteins and their annotated locations for NP_417691.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6D0IBD6, A0AAN5ZJP1
    Conserved Domains (1) summary
    PRK03893
    Location:1 → 496
    PRK03893; putative sialic acid transporter; Provisional
Nucleotide Protein
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