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mlaE intermembrane phospholipid transport system, integral membrane subunit MlaE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947732, updated on 8-Apr-2026
Official Symbol
mlaE
Official Full Name
intermembrane phospholipid transport system, integral membrane subunit MlaE
Primary source
ECOCYC:EG12800
Locus tag
b3194
See related
ASAP:ABE-0010495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3183; yrbE
Summary
YrbE is in an operon with ABC transporter homologs and may be a permease protein. [More information is available at EcoGene: EG12800]. Yrbe is the membrane component of a predicted ABC superfamily toluene efflux transporter. [More information is available at EcoCyc: EG12800].
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Sequence:
NC_000913.3 (3338466..3339248, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene intermembrane phospholipid transport system protein MlaB Neighboring gene intermembrane phospholipid transport system - periplasmic binding protein Neighboring gene intermembrane phospholipid transport system, substrate binding protein MlaD Neighboring gene intermembrane phospholipid transport system, ATP binding subunit MlaF Neighboring gene putative transport protein YrbG

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Tang X, et al. Nat Struct Mol Biol, 2021 Jan. PMID 33199922
  2. Unanticipated functional diversity among the TatA-type components of the Tat protein translocase. Eimer E, et al. Sci Rep, 2018 Jan 22. PMID 29358647, Free PMC Article
  3. Identification of two Shigella flexneri chromosomal loci involved in intercellular spreading. Hong M, et al. Infect Immun, 1998 Oct. PMID 9746567, Free PMC Article
  4. Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Zhang N, et al. Proteomics, 2007 Feb. PMID 17309111
  5. Genome-wide screening of genes required for swarming motility in Escherichia coli K-12. Inoue T, et al. J Bacteriol, 2007 Feb. PMID 17122336, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables phospholipid transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within intermembrane phospholipid transfer IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
Preferred Names
intermembrane phospholipid transport system, integral membrane subunit MlaE

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3338466..3339248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417661.1 intermembrane phospholipid transport system, integral membrane subunit MlaE

    See identical proteins and their annotated locations for NP_417661.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7A6NPI5
    Conserved Domains (1) summary
    NF033619
    Location:7 → 259
    perm_MlaE_1; lipid asymmetry maintenance ABC transporter permease subunit MlaE
Nucleotide Protein
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