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mlaF intermembrane phospholipid transport system, ATP binding subunit MlaF [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947729, updated on 26-Mar-2025

Summary

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Official Symbol
mlaF
Official Full Name
intermembrane phospholipid transport system, ATP binding subunit MlaF
Primary source
ECOCYC:EG12801
Locus tag
b3195
See related
ASAP:ABE-0010498
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3184; yrbF
Summary
YrbF is the ATP-binding component of a predicted ABC superfamily toluene efflux transporter. [More information is available at EcoCyc: EG12801].
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Genomic context

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Sequence:
NC_000913.3 (3339256..3340065, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene intermembrane phospholipid transport system, substrate binding protein MlaD Neighboring gene intermembrane phospholipid transport system, integral membrane subunit MlaE Neighboring gene putative transport protein YrbG Neighboring gene D-arabinose 5-phosphate isomerase KdsD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation. Kolich LR, et al. Elife, 2020 Jun 30. PMID 32602838, Free PMC Article
  2. Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Tang X, et al. Nat Struct Mol Biol, 2021 Jan. PMID 33199922
  3. Unanticipated functional diversity among the TatA-type components of the Tat protein translocase. Eimer E, et al. Sci Rep, 2018 Jan 22. PMID 29358647, Free PMC Article
  4. Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry. Thong S, et al. Elife, 2016 Aug 16. PMID 27529189, Free PMC Article
  5. Identification of two Shigella flexneri chromosomal loci involved in intercellular spreading. Hong M, et al. Infect Immun, 1998 Oct. PMID 9746567, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within intermembrane phospholipid transfer IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of phospholipid-translocating ATPase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
intermembrane phospholipid transport system, ATP binding subunit MlaF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3339256..3340065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417662.1 intermembrane phospholipid transport system, ATP binding subunit MlaF [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417662.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2W6PHR2
    Conserved Domains (1) summary
    PRK11831
    Location:2 → 269
    PRK11831; phospholipid ABC transporter ATP-binding protein MlaF
Nucleotide Protein
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