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lptC lipopolysaccharide transport system protein LptC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947722, updated on 19-Nov-2025
Official Symbol
lptC
Official Full Name
lipopolysaccharide transport system protein LptC
Primary source
ECOCYC:G7664
Locus tag
b3199
See related
ASAP:ABE-0010508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3188; yrbK
Summary
Overexpression causes abnormal biofilm architecture. [More information is available at EcoGene: EG12806]. YrbK is predicted to be an integral membrane component of the LptAB-YrbK ABC transporter. [More information is available at EcoCyc: G7664].
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Sequence:
NC_000913.3 (3342836..3343411)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transport protein YrbG Neighboring gene D-arabinose 5-phosphate isomerase KdsD Neighboring gene 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC Neighboring gene lipopolysaccharide transport system protein LptA Neighboring gene lipopolysaccharide transport system ATP binding protein LptB Neighboring gene RNA polymerase sigma factor RpoN

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterization of and lipopolysaccharide binding to the E. coli LptC protein dimer. Schultz KM, et al. Protein Sci, 2018 Feb. PMID 29024084, Free PMC Article
  2. Structure and functional analysis of LptC, a conserved membrane protein involved in the lipopolysaccharide export pathway in Escherichia coli. Tran AX, et al. J Biol Chem, 2010 Oct 22. PMID 20720015, Free PMC Article
  3. Disruption of the E. coli LptC dimerization interface and characterization of lipopolysaccharide and LptA binding to monomeric LptC. Schultz KM, et al. Protein Sci, 2018 Aug. PMID 29672978, Free PMC Article
  4. The transmembrane α-helix of LptC participates in LPS extraction by the LptB(2) FGC transporter. Wilson A, et al. Mol Microbiol, 2022 Jul. PMID 35678757, Free PMC Article
  5. Structural basis of lipopolysaccharide extraction by the LptB(2)FGC complex. Li Y, et al. Nature, 2019 Mar. PMID 30894744, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transmembrane alpha-helix of LptC participates in LPS extraction by the LptB2 FGC transporter.
    Title: The transmembrane α-helix of LptC participates in LPS extraction by the LptB(2) FGC transporter.
  2. Characterized interactions and binding of lipopolysaccharide transport system proteins LptA and LptC thru dimerization and point mutation studies.
    Title: Disruption of the E. coli LptC dimerization interface and characterization of lipopolysaccharide and LptA binding to monomeric LptC.
  3. Characterization of and lipopolysaccharide binding to the E. coli LptC protein dimer has been reported.
    Title: Characterization of and lipopolysaccharide binding to the E. coli LptC protein dimer.
  4. LptC was included in the ABC transporter Lpt protein complex.
    Title: Biochemical characterization of an ABC transporter LptBFGC complex required for the outer membrane sorting of lipopolysaccharides.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycolipid transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycolipid transfer activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipopolysaccharide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Gram-negative-bacterium-type cell outer membrane assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipopolysaccharide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of transporter complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
lipopolysaccharide transport system protein LptC
NP_417666.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3342836..3343411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417666.1 lipopolysaccharide transport system protein LptC

    See identical proteins and their annotated locations for NP_417666.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9ANF2, A0A6L7CG65
    Conserved Domains (1) summary
    PRK10893
    Location:1 → 191
    PRK10893; LPS export ABC transporter periplasmic protein LptC
Nucleotide Protein
Heading Accession and Version

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