U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

secG Sec translocon subunit SecG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947720, updated on 3-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
secG
Official Full Name
Sec translocon subunit SecG
Primary source
ECOCYC:EG12095
Locus tag
b3175
See related
ASAP:ABE-0010436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3164; prlH
Summary
SecYEG complex interacts with SecDFyajC to form a hexameric holocomplex. [More information is available at EcoGene: EG12095]. SecG is an inner membrane protein involved in the Sec protein secretion pathway. [More information is available at EcoCyc: EG12095].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (3322173..3322505, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative hydrolase YhbX Neighboring gene tRNA-Leu Neighboring gene phosphoglucosamine mutase Neighboring gene dihydropteroate synthase Neighboring gene ATP-dependent zinc metalloprotease FtsH

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Membrane topology inversion of SecG detected by labeling with a membrane-impermeable sulfhydryl reagent that causes a close association of SecG with SecA. Nagamori S, et al. J Biochem, 2002 Oct. PMID 12359079
  2. A new genetic selection identifies essential residues in SecG, a component of the Escherichia coli protein export machinery. Bost S, et al. EMBO J, 1995 Sep 15. PMID 7556084, Free PMC Article
  3. prl mutations in the Escherichia coli secG gene. Bost S, et al. J Biol Chem, 1997 Feb 14. PMID 9020118
  4. Escherichia coli preprotein translocase. Wickner W, et al. J Biol Chem, 1996 Nov 22. PMID 8939874
  5. Stabilised secondary structure at a ribosomal binding site enhances translational repression in E. coli. Brunel C, et al. J Mol Biol, 1995 Oct 20. PMID 7563089

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparison of Single and Multiple Turnovers of SecYEG in Escherichia coli.
    Title: Comparison of Single and Multiple Turnovers of SecYEG in Escherichia coli.
  2. SecA gains access to the SecYEG complex via a lipid-bound intermediate state, whereas acidic phospholipids allosterically activate SecA for ATP-dependent protein translocation.
    Title: Lipids Activate SecA for High Affinity Binding to the SecYEG Complex.
  3. Authors show that SecG plays a critical role for the residual export mediated by mutant signal sequences and that the SecYE dimer can often be detected only in the presence of SecG.
    Title: Escherichia coli SecG is required for residual export mediated by mutant signal sequences and for SecY-SecE complex stability.
  4. The hydrophobicity threshold for SecYEG-mediated cell membrane insertion is distinctly lower than that for Sec61-mediated insertion.
    Title: Quantitative analysis of SecYEG-mediated insertion of transmembrane α-helices into the bacterial inner membrane.
  5. Data show that ribosome binding is sufficient to open the SecYEG channel.
    Title: The bacterial translocon SecYEG opens upon ribosome binding.
  6. Data indicate taht SecG inversion occurs only when MPIase associates with SecYEG.
    Title: Glycolipozyme MPIase is essential for topology inversion of SecG during preprotein translocation.
  7. Charge composition features of model single-span membrane proteins that determine selection of YidC and SecYEG translocase pathways in Escherichia coli
    Title: Charge composition features of model single-span membrane proteins that determine selection of YidC and SecYEG translocase pathways in Escherichia coli.
  8. The observed conformational changes thus position SecA for productive interaction with the SecYEG translocon and for transfer of segments of its passenger protein across the translocon
    Title: Using a low denaturant model to explore the conformational features of translocation-active SecA.
  9. SecA can promote protein translocation and ion channel activities both when it is bound to lipids at low affinity sites and when it is bound to SecYEG with high affinity.
    Title: SecA alone can promote protein translocation and ion channel activity: SecYEG increases efficiency and signal peptide specificity.
  10. analysis of conformational dynamics of the plug domain of the SecYEG protein-conducting channel
    Title: Conformational dynamics of the plug domain of the SecYEG protein-conducting channel.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-transporting ATPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane, translocation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular protein transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intracellular protein transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein insertion into membrane from inner side IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein insertion into membrane from inner side IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport by the Sec complex IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport by the Sec complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport by the Sec complex IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of cell envelope Sec protein transport complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cell envelope Sec protein transport complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Sec translocon subunit SecG

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3322173..3322505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417642.1 Sec translocon subunit SecG [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417642.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376LEN0
    Conserved Domains (1) summary
    COG1314
    Location:1 → 81
    SecG; Preprotein translocase subunit SecG [Intracellular trafficking, secretion, and vesicular transport]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.