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hpf [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947718, updated on 11-Sep-2024

Summary

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Official Symbol
hpf
Primary source
ECOCYC:EG11681
Locus tag
b3203
See related
ASAP:ABE-0010516
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3192; yhbH
Summary
Homologous to RpoN modulators. [More information is available at EcoGene: EG11681]. YhbH binds to 100S ribosome dimers while YfiA binds to 70S ribosomes at stationary phase . [More information is available at EcoCyc: EG11681].
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Genomic context

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Sequence:
NC_000913.3 (3346173..3346460)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipopolysaccharide transport system ATP binding protein LptB Neighboring gene RNA polymerase sigma factor RpoN Neighboring gene phosphotransferase system enzyme IIA(Ntr) Neighboring gene RNase adaptor protein RapZ Neighboring gene phosphorelay protein NPr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solution structure of the E. coli ribosome hibernation promoting factor HPF: Implications for the relationship between structure and function. Sato A, et al. Biochem Biophys Res Commun, 2009 Nov 27. PMID 19747895
  2. Role of HPF (hibernation promoting factor) in translational activity in Escherichia coli. Ueta M, et al. J Biochem, 2008 Mar. PMID 18174192
  3. Ribosome binding proteins YhbH and YfiA have opposite functions during 100S formation in the stationary phase of Escherichia coli. Ueta M, et al. Genes Cells, 2005 Dec. PMID 16324148
  4. Two proteins, YfiA and YhbH, associated with resting ribosomes in stationary phase Escherichia coli. Maki Y, et al. Genes Cells, 2000 Dec. PMID 11168583
  5. ppGpp ribosome dimerization model for bacterial persister formation and resuscitation. Song S, et al. Biochem Biophys Res Commun, 2020 Mar 5. PMID 32007277

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. crystal structure of Thermus thermophilus 70S ribosome in complex with stationary-phase factors RMF, HPF and YfiA; the nearly identical binding sites of HPF and YfiA overlap with those of the mRNA, transfer RNA and initiation factors which prevents translation initiation
    Title: How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.
  2. the first solution structure of HPF as determined by multi-dimensional NMR was reported.
    Title: Solution structure of the E. coli ribosome hibernation promoting factor HPF: Implications for the relationship between structure and function.
  3. Ribosomes change into forms which are hard to bind with IF3 and easy to form 100S ribosomes by RMF and HPF concomitantly with transition from the log phase to the stationary phase.
    Title: Activities of Escherichia coli ribosomes in IF3 and RMF change to prepare 100S ribosome formation on entering the stationary growth phase.
  4. N-terminus verified by Edman degradation on complete protein
    Title: Two proteins, YfiA and YhbH, associated with resting ribosomes in stationary phase Escherichia coli.
  5. Since 100S particles were seen in the yfiA deletion mutant containing RMF and YhbH, YhbH probably converts immature 90S ribosomes into mature 100S particles.
    Title: Ribosome binding proteins YhbH and YfiA have opposite functions during 100S formation in the stationary phase of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal small subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in dormancy process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribosome hibernation-promoting factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3346173..3346460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417670.1 ribosome hibernation-promoting factor [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417670.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M292
    Conserved Domains (1) summary
    PRK10470
    Location:1 → 95
    PRK10470; ribosome hibernation promoting factor
Nucleotide Protein
Heading Accession and Version

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