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iraP anti-adaptor protein IraP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947709, updated on 30-Jul-2025
Official Symbol
iraP
Official Full Name
anti-adaptor protein IraP
Primary source
ECOCYC:EG11256
Locus tag
b0382
See related
ASAP:ABE-0001313
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0377; yaiB
Summary
IraP interferes with RssB, ClpXP-dependent degradation of RpoS by interacting directly with RssB. [More information is available at EcoGene: EG11256]. IraP is an anti-adaptor protein that is required for stabilization of the alternative sigma factor S during phosphate starvation and plays a role in stationary phase and nitrogen starvation. [More information is available at EcoCyc: EG11256].
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Sequence:
NC_000913.3 (401386..401646)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2754 domain-containing protein YaiZ Neighboring gene D-alanine--D-alanine ligase A Neighboring gene alkaline phosphatase Neighboring gene phosphate starvation-inducible protein PsiF

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The molecular evolution of bacterial alkaline phosphatase: correlating variation among enteric bacteria to experimental manipulations of the protein. DuBose RF, et al. Mol Biol Evol, 1990 Nov. PMID 2129542
  2. The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica. Tu X, et al. Proc Natl Acad Sci U S A, 2006 Sep 5. PMID 16938894, Free PMC Article
  3. The nucleotide sequence of the promoter and the amino-terminal region of alkaline phosphatase structural gene (phoA) of Escherichia coli. Kikuchi Y, et al. Nucleic Acids Res, 1981 Nov 11. PMID 6273802, Free PMC Article
  4. Biofilm formation-gene expression relay system in Escherichia coli: modulation of sigmaS-dependent gene expression by the CsgD regulatory protein via sigmaS protein stabilization. Gualdi L, et al. J Bacteriol, 2007 Nov. PMID 17873038, Free PMC Article
  5. Modulating RssB activity: IraP, a novel regulator of sigma(S) stability in Escherichia coli. Bougdour A, et al. Genes Dev, 2006 Apr 1. PMID 16600914, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables anti-sigma factor antagonist activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to phosphate starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to phosphate starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to starvation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
anti-adaptor protein IraP

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    401386..401646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414916.1 anti-adaptor protein IraP

    See identical proteins and their annotated locations for NP_414916.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A793I168
    Conserved Domains (1) summary
    PRK10244
    Location:1 → 86
    PRK10244; anti-adapter protein IraP
Nucleotide Protein
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