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acrE multidrug efflux pump membrane fusion lipoprotein AcrE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947706, updated on 4-Feb-2026
Official Symbol
acrE
Official Full Name
multidrug efflux pump membrane fusion lipoprotein AcrE
Primary source
ECOCYC:EG10266
Locus tag
b3265
See related
ASAP:ABE-0010722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3252; envC
Summary
AcrE is attached to the inner membrane. [More information is available at EcoGene: EG10266]. AcrEF is a multidrug efflux system in Escherichia coli that is highly homologous to the AcrAB multidrug efflux system . [More information is available at EcoCyc: EG10266].
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Sequence:
NC_000913.3 (3413864..3415021)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2556 domain-containing protein YhdU Neighboring gene DNA-binding transcriptional repressor EnvR Neighboring gene multidrug efflux pump RND permease AcrF Neighboring gene lipoprotein YhdV

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Locations of the envCD genes on the physical map of the Escherichia coli chromosome. Klein JR, et al. J Bacteriol, 1992 Jun. PMID 1592834, Free PMC Article
  2. Morphological mutants of Escherichia coli K12. Mapping of the env C mutation. Rodolakis A, et al. Mol Gen Genet, 1974 May 21. PMID 4600017
  3. EnvC, a new lipoprotein of the cytoplasmic membrane of Escherichia coli. Seiffer D, et al. FEMS Microbiol Lett, 1993 Mar 1. PMID 8472900
  4. Dynamics of the trimeric AcrB transporter protein inferred from a B-factor analysis of the crystal structure. Lu WC, et al. Proteins, 2006 Jan 1. PMID 16288462, Free PMC Article
  5. Role of multiple efflux pumps in Escherichia coli in indole expulsion. Kawamura-Sato K, et al. FEMS Microbiol Lett, 1999 Oct 15. PMID 10518736

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that the E. coli AcrEF transporter is expressed under standard laboratory conditions and plays an important role in the normal maintenance of cell division.
    Title: Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC.
  2. normal mode analyses to study important regions for drug recognition and extrusion in this transporter
    Title: Dynamics of the trimeric AcrB transporter protein inferred from a B-factor analysis of the crystal structure.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to antibiotic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane EXP
Inferred from Experiment
more info
 PubMed 
involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
multidrug efflux pump membrane fusion lipoprotein AcrE

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3413864..3415021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417731.1 multidrug efflux pump membrane fusion lipoprotein AcrE

    See identical proteins and their annotated locations for NP_417731.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6M9X1W5
    Conserved Domains (1) summary
    PRK15030
    Location:1 → 384
    PRK15030; multidrug efflux RND transporter periplasmic adaptor subunit AcrA
Nucleotide Protein
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