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rlmE 23S rRNA 2'-O-ribose U2552 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947689, updated on 26-Mar-2025
Official Symbol
rlmE
Official Full Name
23S rRNA 2'-O-ribose U2552 methyltransferase
Primary source
ECOCYC:EG11507
Locus tag
b3179
See related
ASAP:ABE-0010447
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3168; ftsJ; mrsF; rrmJ
Summary
RlmE is the methyltransferase responsible for methylation of 23S rRNA at the 2'-O position of the ribose at the universally conserved U2552 nucleotide . [More information is available at EcoCyc: EG11507].
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Sequence:
NC_000913.3 (3327035..3327664, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphoglucosamine mutase Neighboring gene dihydropteroate synthase Neighboring gene ATP-dependent zinc metalloprotease FtsH Neighboring gene ribosome assembly factor YhbY Neighboring gene transcription elongation factor GreA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Active site in RrmJ, a heat shock-induced methyltransferase. Hager J, et al. J Biol Chem, 2002 Nov 1. PMID 12181314
  2. Substrate binding analysis of the 23S rRNA methyltransferase RrmJ. Hager J, et al. J Bacteriol, 2004 Oct. PMID 15375145, Free PMC Article
  3. U2552 methylation at the ribosomal A-site is a negative modulator of translational accuracy. Widerak M, et al. Gene, 2005 Feb 28. PMID 15715963
  4. Interaction of an essential Escherichia coli GTPase, Der, with the 50S ribosome via the KH-like domain. Hwang J, et al. J Bacteriol, 2010 Apr. PMID 20172997, Free PMC Article
  5. Structure and function of the ftsH gene in Escherichia coli. Ogura T, et al. Res Microbiol, 1991 Feb-Apr. PMID 1925026

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The rrmJ deletion causes a severe growth defect but the growth impairment can be suppressed by overexpression of Der.
    Title: Interaction of an essential Escherichia coli GTPase, Der, with the 50S ribosome via the KH-like domain.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (uridine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (uridine-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (uridine-2'-O-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA (uridine-2'-O-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ribosomal large subunit assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
23S rRNA 2'-O-ribose U2552 methyltransferase
NP_417646.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3327035..3327664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417646.1 23S rRNA 2'-O-ribose U2552 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417646.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A478LCJ5
    Conserved Domains (1) summary
    PRK11188
    Location:1 → 208
    rrmJ; 23S rRNA (uridine(2552)-2'-O)-methyltransferase RlmE
Nucleotide Protein
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