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hcr NADH oxidoreductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947660, updated on 30-Jul-2025
Official Symbol
hcr
Official Full Name
NADH oxidoreductase
Primary source
ECOCYC:G6456
Locus tag
b0872
See related
ASAP:ABE-0002960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0863; ybjV
Summary
Hcp is in an operon and associated with its substrate, the Hcp hybrid-cluster protein hydroxylamine reductase. [More information is available at EcoGene: EG13691].
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Sequence:
NC_000913.3 (911182..912150, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene low-specificity L-threonine aldolase Neighboring gene pyruvate oxidase Neighboring gene protein S-nitrosylase Neighboring gene L-lysine/thialysine exporter

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure of Escherichia coli class II hybrid cluster protein, HCP, reveals a [4Fe-4S] cluster at the N-terminal protrusion. Fujishiro T, et al. FEBS J, 2021 Dec. PMID 34101368
  2. The roles of the hybrid cluster protein, Hcp and its reductase, Hcr, in high affinity nitric oxide reduction that protects anaerobic cultures of Escherichia coli against nitrosative stress. Wang J, et al. Mol Microbiol, 2016 Jun. PMID 26879449
  3. Genome-wide identification of binding sites for the nitric oxide-sensitive transcriptional regulator NsrR. Efromovich S, et al. Methods Enzymol, 2008. PMID 18433631
  4. Conserved and variable functions of the sigmaE stress response in related genomes. Rhodius VA, et al. PLoS Biol, 2006 Jan. PMID 16336047, Free PMC Article
  5. The hybrid-cluster protein ('prismane protein') from Escherichia coli. Characterization of the hybrid-cluster protein, redox properties of the [2Fe-2S] and [4Fe-2S-2O] clusters and identification of an associated NADH oxidoreductase containing FAD and [2Fe-2S]. van den Berg WA, et al. Eur J Biochem, 2000 Feb. PMID 10651802

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structure of Escherichia coli class II hybrid cluster protein, HCP, reveals a [4Fe-4S] cluster at the N-terminal protrusion.
    Title: Crystal structure of Escherichia coli class II hybrid cluster protein, HCP, reveals a [4Fe-4S] cluster at the N-terminal protrusion.
  2. In an hcr mutant, Hcp is reversibly inactivated by nitric oxide (NO) concentrations above 200 nM, indicating that Hcr protects Hcp from nitrosylation by its substrate, NO.
    Title: The roles of the hybrid cluster protein, Hcp and its reductase, Hcr, in high affinity nitric oxide reduction that protects anaerobic cultures of Escherichia coli against nitrosative stress.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
NADH oxidoreductase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    911182..912150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415393.1 NADH oxidoreductase

    See identical proteins and their annotated locations for NP_415393.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X1NGK6
    Conserved Domains (1) summary
    PRK10684
    Location:1 → 322
    PRK10684; HCP oxidoreductase, NADH-dependent; Provisional
Nucleotide Protein
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