yqjA DedA family protein YqjA [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: yqjA
Official Full Name: DedA family protein YqjA
Primary source: ECOCYC:G7609
Locus tag: b3095
See related: ASAP:ABE-0010181
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ecfL; ECK3086
Summary: A yqjA yghB double mutant has a membrane defect causing a cell division defect at low temperatures and an osmoremedial growth defect at elevated temperatures (Thomkins, 2008). [More information is available at EcoGene: EG12740]. YqjA is a member of the DedA family of inner membrane proteins . [More information is available at EcoCyc: G7609].
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Genomic context

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Sequence:: NC_000913.3 (3247773..3248435)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Topological analysis of a bacterial DedA protein associated with alkaline tolerance and antimicrobial resistance.
Title: Topological analysis of a bacterial DedA protein associated with alkaline tolerance and antimicrobial resistance.
study found that yqjA promoter activity was highest at alkaline pH. Increased activity of the yqjA promoter required both the transcriptional regulator CpxR, in agreement with previous results, and sodium or potassium salts at alkaline pH.
Title: Cpx-dependent expression of YqjA requires cations at elevated pH.
discovery of 2 conserved predicted membrane-embedded arginines (R130 and R136) that are critical for function in both YqjA and YghB; lysine can substitute for arginine at position R130 indicating a charge dependence at this position, but could not substitute at R136; study provides mechanistic insight into YqjA and YghB and supports the hypothesis that they function as membrane transporters
Title: Identification of essential arginine residues of Escherichia coli DedA/Tvp38 family membrane proteins YqjA and YghB.
Periplasmic amidases AmiC and AmiA, secreted by the twin arginine transport (Tat) pathway, are localized to the cytoplasm in Escherichia coli YqjA and YghB double mutant cells.
Title: Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes.
Data show that it is likely that YqjA play critical roles in membrane biology that are essential for completion of cell division in E. coli.
Title: Temperature sensitivity and cell division defects in an Escherichia coli strain with mutations in yghB and yqjA, encoding related and conserved inner membrane proteins.

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General gene information

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Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables transmembrane transporter activity	EXP Inferred from Experiment more info	PubMed
enables transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within FtsZ-dependent cytokinesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	EXP Inferred from Experiment more info	PubMed
acts_upstream_of_or_within transmembrane transport	EXP Inferred from Experiment more info	PubMed
acts_upstream_of_or_within transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	RCA inferred from Reviewed Computational Analysis more info	PubMed

General protein information

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Preferred Names: DedA family protein YqjA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

3247773..3248435

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_417566.1 DedA family protein YqjA [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_417566.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A376FW85, A0A376JTT7

Conserved Domains (1) summary

COG0586
Location:14 → 219

DedA; Uncharacterized membrane protein DedA, SNARE-associated domain [Function unknown]