Sign in to NCBI
Format

Send to:

Choose Destination

yqjA DedA family protein YqjA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947643, updated on 22-Aug-2021

Summary

Go to the top of the page Help
Gene symbol
yqjA
Gene description
DedA family protein YqjA
Primary source
ASAP:ABE-0010181
Locus tag
b3095
See related
ECOCYC:G7609
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ecfL; ECK3086
Summary
A yqjA yghB double mutant has a membrane defect causing a cell division defect at low temperatures and an osmoremedial growth defect at elevated temperatures (Thomkins, 2008). [More information is available at EcoGene: EG12740]. YqjA is a member of the DedA family of inner membrane proteins . [More information is available at EcoCyc: G7609].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (3247773..3248435)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor ExuR Neighboring gene protein YqiM Neighboring gene modulator protein MzrA Neighboring gene DUF1090 domain-containing protein YqjC

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cpx-dependent expression of YqjA requires cations at elevated pH. Kumar S, et al. FEMS Microbiol Lett, 2017 Jul 3. PMID 28591809
  2. Identification of essential arginine residues of Escherichia coli DedA/Tvp38 family membrane proteins YqjA and YghB. Kumar S, et al. FEMS Microbiol Lett, 2016 Jul. PMID 27190159
  3. Members of the conserved DedA family are likely membrane transporters and are required for drug resistance in Escherichia coli. Kumar S, et al. Antimicrob Agents Chemother, 2014. PMID 24277026, Free PMC Article
  4. Temperature sensitivity and cell division defects in an Escherichia coli strain with mutations in yghB and yqjA, encoding related and conserved inner membrane proteins. Thompkins K, et al. J Bacteriol, 2008 Jul. PMID 18456815, Free PMC Article
  5. Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes. Sikdar R, et al. J Bacteriol, 2010 Feb. PMID 19880597, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study found that yqjA promoter activity was highest at alkaline pH. Increased activity of the yqjA promoter required both the transcriptional regulator CpxR, in agreement with previous results, and sodium or potassium salts at alkaline pH.
    Title: Cpx-dependent expression of YqjA requires cations at elevated pH.
  2. discovery of 2 conserved predicted membrane-embedded arginines (R130 and R136) that are critical for function in both YqjA and YghB; lysine can substitute for arginine at position R130 indicating a charge dependence at this position, but could not substitute at R136; study provides mechanistic insight into YqjA and YghB and supports the hypothesis that they function as membrane transporters
    Title: Identification of essential arginine residues of Escherichia coli DedA/Tvp38 family membrane proteins YqjA and YghB.
  3. Periplasmic amidases AmiC and AmiA, secreted by the twin arginine transport (Tat) pathway, are localized to the cytoplasm in Escherichia coli YqjA and YghB double mutant cells.
    Title: Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes.
  4. Data show that it is likely that YqjA play critical roles in membrane biology that are essential for completion of cell division in E. coli.
    Title: Temperature sensitivity and cell division defects in an Escherichia coli strain with mutations in yghB and yqjA, encoding related and conserved inner membrane proteins.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within FtsZ-dependent cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
located_in integral component of plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DedA family protein YqjA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3247773..3248435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417566.1 DedA family protein YqjA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417566.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0AA63
    Conserved Domains (1) summary
    COG0586
    Location:14 → 219
    DedA; Uncharacterized membrane protein DedA, SNARE-associated domain [Function unknown]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
You are here: NCBI > Genes & Expression > Gene
Support Center