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yqjA DedA family protein YqjA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947643, updated on 17-Jul-2025
Official Symbol
yqjA
Official Full Name
DedA family protein YqjA
Primary source
ECOCYC:G7609
Locus tag
b3095
See related
ASAP:ABE-0010181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ecfL; ECK3086
Summary
A yqjA yghB double mutant has a membrane defect causing a cell division defect at low temperatures and an osmoremedial growth defect at elevated temperatures (Thomkins, 2008). [More information is available at EcoGene: EG12740]. YqjA is a member of the DedA family of inner membrane proteins . [More information is available at EcoCyc: G7609].
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Sequence:
NC_000913.3 (3247773..3248435)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor ExuR Neighboring gene protein YqiM Neighboring gene modulator protein MzrA Neighboring gene DUF1090 domain-containing protein YqjC

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Topological analysis of a bacterial DedA protein associated with alkaline tolerance and antimicrobial resistance. Scarsbrook HL, et al. Microbiology (Reading), 2021 Dec. PMID 34914576
  2. Cpx-dependent expression of YqjA requires cations at elevated pH. Kumar S, et al. FEMS Microbiol Lett, 2017 Jul 3. PMID 28591809
  3. Identification of essential arginine residues of Escherichia coli DedA/Tvp38 family membrane proteins YqjA and YghB. Kumar S, et al. FEMS Microbiol Lett, 2016 Jul. PMID 27190159
  4. Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes. Sikdar R, et al. J Bacteriol, 2010 Feb. PMID 19880597, Free PMC Article
  5. Transcriptional response of Escherichia coli to external copper. Yamamoto K, et al. Mol Microbiol, 2005 Apr. PMID 15773991

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Topological analysis of a bacterial DedA protein associated with alkaline tolerance and antimicrobial resistance.
    Title: Topological analysis of a bacterial DedA protein associated with alkaline tolerance and antimicrobial resistance.
  2. study found that yqjA promoter activity was highest at alkaline pH. Increased activity of the yqjA promoter required both the transcriptional regulator CpxR, in agreement with previous results, and sodium or potassium salts at alkaline pH.
    Title: Cpx-dependent expression of YqjA requires cations at elevated pH.
  3. discovery of 2 conserved predicted membrane-embedded arginines (R130 and R136) that are critical for function in both YqjA and YghB; lysine can substitute for arginine at position R130 indicating a charge dependence at this position, but could not substitute at R136; study provides mechanistic insight into YqjA and YghB and supports the hypothesis that they function as membrane transporters
    Title: Identification of essential arginine residues of Escherichia coli DedA/Tvp38 family membrane proteins YqjA and YghB.
  4. Periplasmic amidases AmiC and AmiA, secreted by the twin arginine transport (Tat) pathway, are localized to the cytoplasm in Escherichia coli YqjA and YghB double mutant cells.
    Title: Inefficient Tat-dependent export of periplasmic amidases in an Escherichia coli strain with mutations in two DedA family genes.
  5. Data show that it is likely that YqjA play critical roles in membrane biology that are essential for completion of cell division in E. coli.
    Title: Temperature sensitivity and cell division defects in an Escherichia coli strain with mutations in yghB and yqjA, encoding related and conserved inner membrane proteins.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in FtsZ-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within FtsZ-dependent cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Preferred Names
DedA family protein YqjA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3247773..3248435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417566.1 DedA family protein YqjA

    See identical proteins and their annotated locations for NP_417566.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376FW85, A0A376JTT7
    Conserved Domains (1) summary
    COG0586
    Location:14 → 219
    DedA; Uncharacterized membrane protein DedA, SNARE-associated domain [Function unknown]
Nucleotide Protein
Heading Accession and Version

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