U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

prlF antitoxin PrlF [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947639, updated on 17-Jul-2025
Official Symbol
prlF
Official Full Name
antitoxin PrlF
Primary source
ECOCYC:EG10955
Locus tag
b3129
See related
ASAP:ABE-0010287
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3117; prlFA; sohA
Summary
PrlF is the antitoxin component in the PrlF-YhaV antitoxin-toxin complex. [More information is available at EcoCyc: EG10955].
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000913.3 (3277002..3277337)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene galactarate/D-glucarate transporter GarP Neighboring gene galactarate dehydratase Neighboring gene ribosome-dependent mRNA interferase toxin YhaV Neighboring gene DNA-binding transcriptional repressor AgaR Neighboring gene putative tagatose-1,6-bisphosphate aldolase 1 chaperone

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Enhanced export of beta-galactosidase fusion proteins in prlF mutants is Lon dependent. Snyder WB, et al. J Bacteriol, 1992 Sep. PMID 1512198, Free PMC Article
  2. Identification, cloning, and characterization of the Escherichia coli sohA gene, a suppressor of the htrA (degP) null phenotype. Baird L, et al. J Bacteriol, 1990 Mar. PMID 2407727, Free PMC Article
  3. Mutation prlF1 relieves the lethality associated with export of beta-galactosidase hybrid proteins in Escherichia coli. Kiino DR, et al. J Bacteriol, 1984 Jun. PMID 6233268, Free PMC Article
  4. Increased expression of the bifunctional protein PrlF suppresses overproduction lethality associated with exported beta-galactosidase hybrid proteins in Escherichia coli. Kiino DR, et al. J Bacteriol, 1990 Jan. PMID 2152898, Free PMC Article
  5. prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli. Schmidt O, et al. J Mol Biol, 2007 Sep 28. PMID 17706670, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that prlF and yhaV encode a novel toxin-antitoxin system in Escherichia coli.
    Title: prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables toxin sequestering activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in single-species biofilm formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of toxin-antitoxin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
antitoxin PrlF

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3277002..3277337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417598.1 antitoxin PrlF

    See identical proteins and their annotated locations for NP_417598.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2Y0SKJ1
    Conserved Domains (1) summary
    PRK09974
    Location:4 → 111
    PRK09974; type II toxin-antitoxin system PrlF family antitoxin
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.