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tdcC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947629, updated on 24-Aug-2024

Summary

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Official Symbol
tdcC
Primary source
ECOCYC:EG10991
Locus tag
b3116
See related
ASAP:ABE-0010247
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3105
Summary
HAAAP family. [More information is available at EcoGene: EG10991]. TdcC is a threonine transport system, likely to function as a threonine/proton symporter. [More information is available at EcoCyc: EG10991].
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Genomic context

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Sequence:
NC_000913.3 (3263686..3265017, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2-ketobutyrate formate-lyase/pyruvate formate-lyase 4 Neighboring gene propionate kinase Neighboring gene catabolic threonine dehydratase Neighboring gene DNA-binding transcriptional activator TdcA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel membrane-associated threonine permease encoded by the tdcC gene of Escherichia coli. Sumantran VN, et al. J Bacteriol, 1990 Aug. PMID 2115866, Free PMC Article
  2. Isolation and characterization of an Escherichia coli mutant lacking the major serine transporter, and cloning of a serine transporter gene. Ogawa W, et al. J Biochem, 1997 Dec. PMID 9498571
  3. Deletion of arcA, iclR, and tdcC in Escherichia coli to improve l-threonine production. Ding Z, et al. Biotechnol Appl Biochem, 2019 Sep. PMID 31177569
  4. Molecular characterization of the tdc operon of Escherichia coli K-12. Goss TJ, et al. J Bacteriol, 1988 Nov. PMID 3053659, Free PMC Article
  5. Physical linkage and transcriptional orientation of the tdc operon on the Escherichia coli chromosome. Schweizer HP, et al. Mol Gen Genet, 1991 Aug. PMID 1886605

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggest that deletion of arcA, iclR, and tdcC could efficiently increase l-threonine production in E. coli.
    Title: Deletion of arcA, iclR, and tdcC in Escherichia coli to improve l-threonine production.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-serine transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables L-serine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables L-serine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-threonine transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables L-threonine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables threonine efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-serine transport EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within L-serine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within amino acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in serine transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within threonine transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in threonine transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within threonine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
threonine/serine:H(+) symporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3263686..3265017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417586.1 threonine/serine:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417586.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377C4J2
    Conserved Domains (1) summary
    PRK13629
    Location:1 → 443
    PRK13629; threonine/serine transporter TdcC; Provisional
Nucleotide Protein
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