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tdcE 2-ketobutyrate formate-lyase/pyruvate formate-lyase 4 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947623, updated on 26-Mar-2025
Official Symbol
tdcE
Official Full Name
2-ketobutyrate formate-lyase/pyruvate formate-lyase 4
Primary source
ECOCYC:G7627
Locus tag
b3114
See related
ASAP:ABE-0010242
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3103; yhaS
Summary
HT_Cmplx9_Cyt: [More information is available at EcoGene: EG12758].
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Sequence:
NC_000913.3 (3260124..3262418, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-serine deaminase III Neighboring gene putative enamine/imine deaminase Neighboring gene propionate kinase Neighboring gene threonine/serine:H(+) symporter

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The glycyl-radical enzyme 2-ketobutyrate formate-lyase, TdcE, interacts specifically with the formate-translocating FNT-channel protein FocA. Falke D, et al. Biochem Biophys Rep, 2016 Jul. PMID 28955877, Free PMC Article
  2. Structure and function of enzymes involved in the anaerobic degradation of L-threonine to propionate. Simanshu DK, et al. J Biosci, 2007 Sep. PMID 17954980
  3. A novel mechanism controls anaerobic and catabolite regulation of the Escherichia coli tdc operon. Sawers G. Mol Microbiol, 2001 Mar. PMID 11251844
  4. Physical map location of the tdc operon of Escherichia coli. Schweizer HP, et al. J Bacteriol, 1990 Jun. PMID 2188941, Free PMC Article
  5. Eliminating side products and increasing succinate yields in engineered strains of Escherichia coli C. Jantama K, et al. Biotechnol Bioeng, 2008 Dec 1. PMID 18781696

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-ketobutyrate formate-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-ketobutyrate formate-lyase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables formate C-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables formate C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-threonine catabolic process to propionate IC
Inferred by Curator
more info
 PubMed 
involved_in L-threonine catabolic process to propionate IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
2-ketobutyrate formate-lyase/pyruvate formate-lyase 4
YP_026205.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3260124..3262418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026205.1 2-ketobutyrate formate-lyase/pyruvate formate-lyase 4 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026205.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FVQ8, A0A376MJ46, A0A377C2L1, A0A8T5Z7G9
    Conserved Domains (1) summary
    cd01678
    Location:15 → 760
    PFL1; Pyruvate formate lyase 1
Nucleotide Protein
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