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ycgR flagellar brake protein YcgR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947609, updated on 23-Apr-2026
Official Symbol
ycgR
Official Full Name
flagellar brake protein YcgR
Primary source
ECOCYC:G6623
Locus tag
b1194
See related
ASAP:ABE-0004009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1182
Summary
YcgR contains a C-terminal PilZ domain, which binds cyclic-di-GMP; binding of c-di-GMP is involved in motility regulation. [More information is available at EcoGene: EG13899]. YcgR regulates flagellar motility in a c-di-GMP-dependent manner in vivo . [More information is available at EcoCyc: G6623].
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Sequence:
NC_000913.3 (1243793..1244527, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene murein tetrapeptide carboxypeptidase Neighboring gene lytic murein transglycosylase E Neighboring gene PF04226 family protein YmgE Neighboring gene uncharacterized protein YcgY

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli. Hou YJ, et al. J Biol Chem, 2020 Jan 17. PMID 31836667, Free PMC Article
  2. Crystallization and preliminary X-ray analysis of the flagellar motor `brake' molecule YcgR with c-di-GMP from Escherichia coli. Hou Y, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Jun. PMID 23722848, Free PMC Article
  3. Get the message out: cyclic-Di-GMP regulates multiple levels of flagellum-based motility. Wolfe AJ, et al. J Bacteriol, 2008 Jan. PMID 17993515, Free PMC Article
  4. Two novel flagellar components and H-NS are involved in the motor function of Escherichia coli. Ko M, et al. J Mol Biol, 2000 Oct 27. PMID 11031114
  5. The flagellar sigma factor FliA regulates adhesion and invasion of Crohn disease-associated Escherichia coli via a cyclic dimeric GMP-dependent pathway. Claret L, et al. J Biol Chem, 2007 Nov 16. PMID 17827157

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli.
    Title: Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli.
  2. The crystal structure and structure-function relationship is revealed for YcgR with c-di-GMP.
    Title: Crystallization and preliminary X-ray analysis of the flagellar motor `brake' molecule YcgR with c-di-GMP from Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cyclic-di-GMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclic-di-GMP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within bacterial-type flagellum-dependent cell motility EXP
Inferred from Experiment
more info
 PubMed 
involved_in bacterial-type flagellum-dependent cell motility IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bacterial-type flagellum-dependent cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of bacterial-type flagellum-dependent cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in bacterial-type flagellum basal body IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
flagellar brake protein YcgR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1243793..1244527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415712.1 flagellar brake protein YcgR

    See identical proteins and their annotated locations for NP_415712.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1V2FV81, A0A8S7CU49
    Conserved Domains (1) summary
    COG5581
    Location:1 → 242
    YcgR; c-di-GMP-binding flagellar brake protein YcgR, contains PilZNR and PilZ domains [Cell motility]
Nucleotide Protein
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