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higA antitoxin/DNA-binding transcriptional repressor HigA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947593, updated on 30-Jul-2025
Official Symbol
higA
Official Full Name
antitoxin/DNA-binding transcriptional repressor HigA
Primary source
ECOCYC:G7601
Locus tag
b3082
See related
ASAP:ABE-0010126
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3072; ygjM
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Sequence:
NC_000913.3 (3233728..3234144, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycoside hydrolase Neighboring gene 2,4-dienoyl-CoA reductase Neighboring gene ribosome-dependent mRNA interferase toxin HigB Neighboring gene 23S rRNA m(2)G1835 methyltransferase Neighboring gene putative metal-dependent hydrolase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Conformational changes of antitoxin HigA from Escherichia coli str. K-12 upon binding of its cognate toxin HigB reveal a new regulation mechanism in toxin-antitoxin systems. Xu BS, et al. Biochem Biophys Res Commun, 2019 Jun 18. PMID 31014676
  2. Structural insight into the E. coli HigBA complex. Yang J, et al. Biochem Biophys Res Commun, 2016 Sep 30. PMID 27601326
  3. Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Christensen-Dalsgaard M, et al. Mol Microbiol, 2010 Jan. PMID 19943910, Free PMC Article
  4. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article
  5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables core promoter sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of growth NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of toxin-antitoxin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of toxin-antitoxin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
antitoxin/DNA-binding transcriptional repressor HigA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3233728..3234144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417553.1 antitoxin/DNA-binding transcriptional repressor HigA

    See identical proteins and their annotated locations for NP_417553.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9AQM8, A0A7A6PX74
    Conserved Domains (1) summary
    COG5499
    Location:17 → 138
    HigA; Antitoxin component HigA of the HigAB toxin-antitoxin module, contains an N-terminal HTH domain [Defense mechanisms]
Nucleotide Protein
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