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bluF blue light- and temperature-regulated antirepressor BluF [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947592, updated on 19-Feb-2025

Summary

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Official Symbol
bluF
Official Full Name
blue light- and temperature-regulated antirepressor BluF
Primary source
ECOCYC:G6603
Locus tag
b1163
See related
ASAP:ABE-0003903
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1150; ycgF
Summary
YcgF has an N-terminal blue light-responsive FAD-binding BLUF domain. [More information is available at EcoGene: EG13887]. YcgF is a member of the family of blue-light sensing proteins that use FAD (BLUF). [More information is available at EcoCyc: G6603].
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Genomic context

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Sequence:
NC_000913.3 (1214264..1215475, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1398 domain-containing protein YcgX Neighboring gene DNA-binding transcriptional repressor BluR Neighboring gene putative two-component system connector protein YcgZ Neighboring gene putative two-component system connector protein YmgA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transient dimerization and conformational change of a BLUF protein: YcgF. Nakasone Y, et al. J Am Chem Soc, 2007 Jun 6. PMID 17489591
  2. Analysis of proton wires in the enzyme active site suggests a mechanism of c-di-GMP hydrolysis by the EAL domain phosphodiesterases. Grigorenko BL, et al. Proteins, 2016 Nov. PMID 27479508
  3. AppA, a redox regulator of photosystem formation in Rhodobacter sphaeroides 2.4.1, is a flavoprotein. Identification of a novel fad binding domain. Gomelsky M, et al. J Biol Chem, 1998 Dec 25. PMID 9857073
  4. Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli. Rajagopal S, et al. Photochem Photobiol, 2004 Nov-Dec. PMID 15453820
  5. Influence of a joining helix on the BLUF domain of the YcgF photoreceptor from Escherichia coli. Schroeder C, et al. Chembiochem, 2008 Oct 13. PMID 18792053

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of proton wires in the enzyme active site suggests a mechanism of c-di-GMP hydrolysis by the EAL domain Blrp (bluF).
    Title: Analysis of proton wires in the enzyme active site suggests a mechanism of c-di-GMP hydrolysis by the EAL domain phosphodiesterases.
  2. Data identified the BluR binding site in the ycgZ promoter and observed that BluR also has residual affinity for the MlrA-dependent csgD promoter.
    Title: Molecular function and potential evolution of the biofilm-modulating blue light-signalling pathway of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables blue light photoreceptor activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclic-guanylate-specific phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclic-guanylate-specific phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables photoreceptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blue light signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of single-species biofilm formation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to blue light IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
blue light- and temperature-regulated antirepressor BluF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1214264..1215475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415681.1 blue light- and temperature-regulated antirepressor BluF [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415681.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1JFN0
    Conserved Domains (2) summary
    smart01034
    Location:2 → 93
    BLUF; Sensors of blue-light using FAD
    smart00052
    Location:150 → 389
    EAL; Putative diguanylate phosphodiesterase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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