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higB ribosome-dependent mRNA interferase toxin HigB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947591, updated on 6-Jul-2026
Official Symbol
higB
Official Full Name
ribosome-dependent mRNA interferase toxin HigB
Primary source
ECOCYC:G7602
Locus tag
b3083
See related
ASAP:ABE-0010128
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3073; ygjN
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Sequence:
NC_000913.3 (3234141..3234455, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycoside hydrolase Neighboring gene 2,4-dienoyl-CoA reductase Neighboring gene antitoxin/DNA-binding transcriptional repressor HigA Neighboring gene 23S rRNA m(2)G1835 methyltransferase Neighboring gene putative metal-dependent hydrolase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Conformational changes of antitoxin HigA from Escherichia coli str. K-12 upon binding of its cognate toxin HigB reveal a new regulation mechanism in toxin-antitoxin systems. Xu BS, et al. Biochem Biophys Res Commun, 2019 Jun 18. PMID 31014676
  2. Structural insight into the E. coli HigBA complex. Yang J, et al. Biochem Biophys Res Commun, 2016 Sep 30. PMID 27601326
  3. Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Christensen-Dalsgaard M, et al. Mol Microbiol, 2010 Jan. PMID 19943910, Free PMC Article
  4. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article
  5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mRNA stability IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of toxin-antitoxin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of toxin-antitoxin complex IEA
Inferred from Electronic Annotation
more info
  
part_of toxin-antitoxin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
ribosome-dependent mRNA interferase toxin HigB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3234141..3234455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417554.1 ribosome-dependent mRNA interferase toxin HigB

    See identical proteins and their annotated locations for NP_417554.1

    Status: REVIEWED

    Conserved Domains (1) summary
    COG4680
    Location:1 → 99
    HigB; mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version

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