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folB dihydroneopterin aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947544, updated on 3-Dec-2024

Summary

Official Symbol
folB
Official Full Name
dihydroneopterin aldolase
Primary source
ECOCYC:EG11673
Locus tag
b3058
See related
ASAP:ABE-0010036
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3048; ygiG
Summary
The N-terminal sequence of native FolB(YgiG) is MDIVFIEQL (Jeff Green, personal comm. [More information is available at EcoGene: EG11673]. Dihydroneopterin aldolase is an enzyme in the tetrahydrofolate biosynthesis pathway, an important antibacterial drug target. [More information is available at EcoCyc: EG11673].
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Genomic context

Sequence:
NC_000913.3 (3204221..3204589, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused CCA tRNA nucleotidyltransferase/phosphohydrolase Neighboring gene undecaprenyl pyrophosphate phosphatase Neighboring gene putative glycerol-3-phosphate acyltransferase Neighboring gene DNA-binding transcriptional activator Dan

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables dihydroneopterin aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dihydroneopterin aldolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dihydroneopterin aldolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in folic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in folic acid-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
dihydroneopterin aldolase
NP_417530.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3204221..3204589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417530.2 dihydroneopterin aldolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417530.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A192CCA2, A0A1X3I373, A0A1X3IXF0, A0A1X3JC03, A0A979GHG2, A0AA36L0H2, A0AAN2BMT3, F4T381, Q1R6S3
    Conserved Domains (1) summary
    PRK11593
    Location:1119
    folB; bifunctional dihydroneopterin aldolase/7,8-dihydroneopterin epimerase