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hemH ferrochelatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947532, updated on 26-Mar-2025

Summary

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Official Symbol
hemH
Official Full Name
ferrochelatase
Primary source
ECOCYC:EG10431
Locus tag
b0475
See related
ASAP:ABE-0001649
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0469; popA; visA
Summary
An hemH mutant shows a defect in iron incorporation into porphyrin that results in a defect in assembly of membrane-associated succinate-ubiquinone reductase . [More information is available at EcoCyc: EG10431].
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Genomic context

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Sequence:
NC_000913.3 (498055..499017)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene chaperone protein HtpG Neighboring gene adenylate kinase Neighboring gene acetylesterase Neighboring gene inosine/guanosine kinase Neighboring gene putative transporter YbaL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Photosensitivity of a protoporphyrin-accumulating, light-sensitive mutant (visA) of Escherichia coli K-12. Nakahigashi K, et al. Proc Natl Acad Sci U S A, 1991 Dec 1. PMID 1835790, Free PMC Article
  2. Biochemistry, regulation and genomics of haem biosynthesis in prokaryotes. O'Brian MR, et al. Adv Microb Physiol, 2002. PMID 12073655
  3. The Escherichia coli visA gene encodes ferrochelatase, the final enzyme of the heme biosynthetic pathway. Frustaci JM, et al. J Bacteriol, 1993 Apr. PMID 8458858, Free PMC Article
  4. Effects of starvation for heme on the synthesis of porphyrins in Escherichia coli. Nakayashiki T, et al. Mol Gen Genet, 1997 Jul. PMID 9267433
  5. Accumulation of protoporphyrin IX in light-sensitive mutants of Escherichia coli. Miyamoto K, et al. FEBS Lett, 1992 Oct 5. PMID 1397280

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Overproduction, purification, and characterization of ferrochelatase from Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ferrochelatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrochelatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrochelatase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrochelatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heme biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protoporphyrinogen IX metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ferrochelatase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    498055..499017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415008.1 ferrochelatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415008.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8NA67
    Conserved Domains (1) summary
    TIGR00109
    Location:1 → 320
    hemH; ferrochelatase
Nucleotide Protein
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