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mdaB NADPH:quinone oxidoreductase MdaB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947512, updated on 9-Mar-2022

Summary

Gene symbol
mdaB
Gene description
NADPH:quinone oxidoreductase MdaB
Primary source
ASAP:ABE-0009946
Locus tag
b3028
See related
ECOCYC:EG12656
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3019; mda66
Summary
MdaB overexpression results in resistance to cytotoxic drugs including adriamycin, etoposide and the tumoricidal agent DMP 840. [More information is available at EcoGene: EG12656]. The MdaB quinone reductase is specific for NADPH and is most active with quinone derivatives and ferricyanide . [More information is available at EcoCyc: EG12656].
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Genomic context

Sequence:
NC_000913.3 (3172530..3173111)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator QseB Neighboring gene sensor histidine kinase QseC Neighboring gene DUF2645 domain-containing inner membrane protein YgiZ Neighboring gene putative quinol monooxygenase YgiN Neighboring gene DNA topoisomerase IV subunit B

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables NADPH dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NADPH dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
 
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NADPH:quinone oxidoreductase MdaB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3172530..3173111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417500.1 NADPH:quinone oxidoreductase MdaB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417500.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0AEY5
    Conserved Domains (1) summary
    COG2249
    Location:3193
    MdaB; Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]