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mqsR mRNA interferase toxin MqsR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947500, updated on 26-Mar-2025

Summary

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Official Symbol
mqsR
Official Full Name
mRNA interferase toxin MqsR
Primary source
ECOCYC:G7572
Locus tag
b3022
See related
ASAP:ABE-0009925
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3013; ygiU
Summary
msqR is induced during biofilm formation. [More information is available at EcoGene: EG13023]. MqsR is a global regulator that controls biofilm formation by inducing motility via the two-component regulatory system QseBC. [More information is available at EcoCyc: G7572].
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Genomic context

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Sequence:
NC_000913.3 (3168248..3168544, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative deoxycholate binding periplasmic protein Neighboring gene antitoxin of the MqsRA toxin-antitoxin system/DNA-binding transcriptional repressor MqsA Neighboring gene DNA-binding transcriptional repressor YgiV Neighboring gene BOF family protein YgiW

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Toxins MazF and MqsR cleave Escherichia coli rRNA precursors at multiple sites. Mets T, et al. RNA Biol, 2017 Jan 2. PMID 27858580, Free PMC Article
  2. Bacterial persistence increases as environmental fitness decreases. Hong SH, et al. Microb Biotechnol, 2012 Jul. PMID 22221537, Free PMC Article
  3. The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. Kasari V, et al. J Bacteriol, 2010 Jun. PMID 20233923, Free PMC Article
  4. Fragmentation of Escherichia coli mRNA by MazF and MqsR. Mets T, et al. Biochimie, 2019 Jan. PMID 30315853
  5. MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli. Yamaguchi Y, et al. J Biol Chem, 2009 Oct 16. PMID 19690171, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MqsR is a noncanonical microbial RNase toxin that is inhibited by antitoxin MqsA via steric blockage of substrate binding.
    Title: MqsR is a noncanonical microbial RNase toxin that is inhibited by antitoxin MqsA via steric blockage of substrate binding.
  2. Fragmentation of Escherichia coli mRNA by MazF and MqsR.
    Title: Fragmentation of Escherichia coli mRNA by MazF and MqsR.
  3. findings show that the cyclic AMP receptor protein (CRP) indirectly upregulates mqsRA transcription; also show that CRP plays an important role in antibiotic persistence, which seems to be partially mediated through MqsRA
    Title: The cyclic AMP receptor protein (CRP) regulates mqsRA, coding for the bacterial toxin-antitoxin gene pair, in Escherichia coli.
  4. Therefore, the more toxic MqsR increases persistence by decreasing the ability of the cell to respond to antibiotic stress through its RpoS-based regulation of acid resistance, multidrug resistance and osmotic resistance systems.
    Title: Bacterial persistence increases as environmental fitness decreases.
  5. MqsA protein was cocrystallized with a 26-mer duplex DNA corresponding to the palindromic region of the mqsRA promoter
    Title: Preliminary crystallographic analysis of the Escherichia coli antitoxin MqsA (YgiT/b3021) in complex with mqsRA promoter DNA.
  6. The MqsR/MqsA TA system controls cell physiology via its own toxicity as well as through its regulation of another toxin, CspD.
    Title: Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD.
  7. The mqsR gene encodes a toxin, and ectopic expression of this gene inhibits growth and induces rapid shutdown of protein synthesis in vivo.
    Title: The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair.
  8. MqsR influences persister formation since deletion of mqsRA reduces persister cell formation and MqsR overexpression increases persister cell formation.
    Title: Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli.
  9. Here, we report multiple individual and complex three-dimensional structures of MqsR and its antitoxin MqsA (B3021), which reveal that MqsR:MqsA form a novel toxin:antitoxin (TA) pair.
    Title: Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties.
  10. MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli
    Title: MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli.
Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA endonuclease activity, producing 3'-phosphomonoesters IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in quorum sensing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA stability IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in single-species biofilm formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in single-species biofilm formation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of toxin-antitoxin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
mRNA interferase toxin MqsR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3168248..3168544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417494.1 mRNA interferase toxin MqsR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417494.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376ZHJ7
    Conserved Domains (1) summary
    cd12869
    Location:2 → 97
    MqsR; Motility quorum-sensing regulator (MqsR)
Nucleotide Protein
Heading Accession and Version

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