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hyfC hydrogenase 4 component C [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947492, updated on 23-Apr-2026
Official Symbol
hyfC
Official Full Name
hydrogenase 4 component C
Primary source
ECOCYC:G7300
Locus tag
b2483
See related
ASAP:ABE-0008183
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2479
Summary
On the basis of sequence similarity to hycBCDEFG, which encodes hydrogenase 3, the ten-gene cluster hyfABCDEFGHIJ was presumed to encode a hydrogenase that interacts with formate dehydrogenase (FdhF) to produce an active formate hydrogenlyase complex. [More information is available at EcoCyc: G7300].
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Sequence:
NC_000913.3 (2603847..2604794)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 4 component A Neighboring gene hydrogenase 4 component B Neighboring gene hydrogenase 4 component D Neighboring gene hydrogenase 4 component E

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Transcriptional control of hydrogen production during mixed carbon fermentation by hydrogenases 4 (hyf) and 3 (hyc) in Escherichia coli. Trchounian K. Gene, 2012 Sep 10. PMID 22771922
  2. Participation of hyf-encoded hydrogenase 4 in molecular hydrogen release coupled with proton-potassium exchange in Escherichia coli. Bagramyan K, et al. Membr Cell Biol, 2001. PMID 11817571
  3. Phosphorylation of ribosomal proteins in HeLa cells infected with vaccinia virus. Kaerlein M, et al. Nature, 1976 Jan 15. PMID 1246353
  4. Expression and regulation of a silent operon, hyf, coding for hydrogenase 4 isoenzyme in Escherichia coli. Self WT, et al. J Bacteriol, 2004 Jan. PMID 14702328, Free PMC Article
  5. A 12-cistron Escherichia coli operon (hyf) encoding a putative proton-translocating formate hydrogenlyase system. Andrews SC, et al. Microbiology (Reading), 1997 Nov. PMID 9387241

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in anaerobic electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaerobic electron transport chain NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in anaerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in formate oxidation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in glucose catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of [Ni-Fe] hydrogenase complex RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
part_of formate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
Preferred Names
hydrogenase 4 component C

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2603847..2604794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416978.4 hydrogenase 4 component C

    See identical proteins and their annotated locations for NP_416978.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8H9XQ94, A0A8T5ZVV1
    Conserved Domains (1) summary
    COG0650
    Location:5 → 313
    HyfC; Formate hydrogenlyase subunit 4 [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version

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