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yqhC DNA-binding transcriptional activator YqhC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947491, updated on 30-Jul-2025
Official Symbol
yqhC
Official Full Name
DNA-binding transcriptional activator YqhC
Primary source
ECOCYC:G7563
Locus tag
b3010
See related
ASAP:ABE-0009884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3002
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Sequence:
NC_000913.3 (3154262..3155218, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cystathionine beta-lyase/L-cysteine desulfhydrase/alanine racemase Neighboring gene DedA family protein YghB Neighboring gene NADPH-dependent aldehyde reductase YqhD Neighboring gene methylglyoxal reductase DkgA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. YqhC regulates transcription of the adjacent Escherichia coli genes yqhD and dkgA that are involved in furfural tolerance. Turner PC, et al. J Ind Microbiol Biotechnol, 2011 Mar. PMID 20676725
  2. Silencing of NADPH-dependent oxidoreductase genes (yqhD and dkgA) in furfural-resistant ethanologenic Escherichia coli. Miller EN, et al. Appl Environ Microbiol, 2009 Jul. PMID 19429550, Free PMC Article
  3. Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12. Lee C, et al. J Bacteriol, 2010 Aug. PMID 20543070, Free PMC Article
  4. The repertoire of DNA-binding transcriptional regulators in Escherichia coli K-12. Pérez-Rueda E, et al. Nucleic Acids Res, 2000 Apr 15. PMID 10734204, Free PMC Article
  5. Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea. Pérez-Rueda E, et al. Comput Biol Chem, 2004 Dec. PMID 15556475

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. yqhC is the positive regulator of the yqhD dkgA operon. Silencing yqhC increases furfural tolerance.
    Title: YqhC regulates transcription of the adjacent Escherichia coli genes yqhD and dkgA that are involved in furfural tolerance.
  2. The authors propose that YqhC is a transcriptional activator of YqhD, which acts as an aldehyde reductase with specificity for certain aldehydes, including glyoxal.
    Title: Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding transcriptional activator YqhC

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3154262..3155218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417483.2 DNA-binding transcriptional activator YqhC

    See identical proteins and their annotated locations for NP_417483.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0D6H8U5, A0A0E2LGH3, A0A7I0L063, B7MA73, B7MZZ7, B7ND01, B7UIR1, S1P7U9
    Conserved Domains (2) summary
    COG2207
    Location:197 → 316
    AraC; AraC-type DNA-binding domain and AraC-containing proteins [Transcription]
    pfam06719
    Location:47 → 198
    AraC_N; AraC-type transcriptional regulator N-terminus
Nucleotide Protein
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