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hybE hydrogenase 2-specific chaperone [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947483, updated on 17-Jul-2025
Official Symbol
hybE
Official Full Name
hydrogenase 2-specific chaperone
Primary source
ECOCYC:EG11803
Locus tag
b2992
See related
ASAP:ABE-0009824
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2986
Summary
HybE plays a role in coordinating assembly and export of the hydrogenase 2 subunits HybO and HybC. [More information is available at EcoCyc: EG11803].
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Sequence:
NC_000913.3 (3140311..3140799, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene disulfide reductase/organic hydroperoxide reductase Neighboring gene hydrogenase maturation factor HybG Neighboring gene hydrogenase maturation protein HybF Neighboring gene hydrogenase 2 maturation protease Neighboring gene hydrogenase 2 large subunit Neighboring gene hydrogenase 2 membrane subunit Neighboring gene hydrogenase 2

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Solution structure of the Escherichia coli HybE reveals a novel fold. Shao X, et al. Proteins, 2009 Jun. PMID 19291739
  2. Assembly of Tat-dependent [NiFe] hydrogenases: identification of precursor-binding accessory proteins. Dubini A, et al. FEBS Lett, 2003 Aug 14. PMID 12914940
  3. Coordinating assembly and export of complex bacterial proteins. Jack RL, et al. EMBO J, 2004 Oct 13. PMID 15385959, Free PMC Article
  4. Common principles in the biosynthesis of diverse enzymes. Jack RL, et al. Biochem Soc Trans, 2005 Feb. PMID 15667278
  5. Comparing system-specific chaperone interactions with their Tat dependent redox enzyme substrates. Chan CS, et al. FEBS Lett, 2010 Nov 19. PMID 20974141, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables preprotein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
hydrogenase 2-specific chaperone

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3140311..3140799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417466.1 hydrogenase 2-specific chaperone

    See identical proteins and their annotated locations for NP_417466.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8T5YEC9
    Conserved Domains (1) summary
    PRK10465
    Location:1 → 159
    PRK10465; hydrogenase-2 assembly chaperone
Nucleotide Protein
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