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gpr L-glyceraldehyde 3-phosphate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947480, updated on 25-Jun-2025
Official Symbol
gpr
Official Full Name
L-glyceraldehyde 3-phosphate reductase
Primary source
ECOCYC:G7558
Locus tag
b3001
See related
ASAP:ABE-0009848
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2995; mgrA; yghZ
Summary
AKR14 family. [More information is available at EcoGene: EG13010]. YghZ is an L-glyceraldehyde 3-phosphate (L-GAP) reductase ; the enzyme is also able to detoxify methylglyoxal at a low rate . [More information is available at EcoCyc: G7558].
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Sequence:
NC_000913.3 (3147897..3148937)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2623 domain-containing protein YghW Neighboring gene pseudo Neighboring gene protein YqhI Neighboring gene UPF0114 family protein YqhA Neighboring gene NADP(+)-dependent aldehyde reductase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Deletion of yghZ in Escherichia coli promotes growth in presence of furfural with xylose as carbon source. Jilani SB. FEMS Microbiol Lett, 2024 Jan 9. PMID 38664064
  2. L-glyceraldehyde 3-phosphate reductase from Escherichia coli is a heme binding protein. Desai KK, et al. Bioorg Chem, 2010 Feb. PMID 20015532
  3. Metabolism of L-glyceraldehyde 3-phosphate in Escherichia coli. Kalyananda MK, et al. J Bacteriol, 1987 Jun. PMID 3294792, Free PMC Article
  4. Restoring a metabolic pathway. Richard JP. ACS Chem Biol, 2008 Oct 17. PMID 18928248
  5. L-Glyceraldehude 3-phosphate, a bactericidal agent. Tang CT, et al. Antimicrob Agents Chemother, 1977 Jan. PMID 319747, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in methylglyoxal catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in methylglyoxal catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methylglyoxal catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
L-glyceraldehyde 3-phosphate reductase
NP_417474.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3147897..3148937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417474.1 L-glyceraldehyde 3-phosphate reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417474.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MIA8, A0A8T6BNK2
    Conserved Domains (1) summary
    PRK09912
    Location:1 → 346
    PRK09912; L-glyceraldehyde 3-phosphate reductase; Provisional
Nucleotide Protein
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