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leuA 2-isopropylmalate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947465, updated on 19-Sep-2024

Summary

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Official Symbol
leuA
Official Full Name
2-isopropylmalate synthase
Primary source
ECOCYC:EG11226
Locus tag
b0074
See related
ASAP:ABE-0000267
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0076
Summary
2-isopropylmalate synthase (LeuA) carries out the first step in leucine biosynthesis. [More information is available at EcoCyc: EG11226].
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Genomic context

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Sequence:
NC_000913.3 (81958..83529, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-isopropylmalate dehydratase subunit LeuC Neighboring gene 3-isopropylmalate dehydrogenase Neighboring gene leu operon leader peptide Neighboring gene DNA-binding transcriptional dual regulator LeuO

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-isopropylmalate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-isopropylmalate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-isopropylmalate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-isopropylmalate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acetyl-CoA C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-leucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-leucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-leucine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
2-isopropylmalate synthase
NP_414616.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    81958..83529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414616.1 2-isopropylmalate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414616.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376L1F6, A0A828NZ64
    Conserved Domains (1) summary
    PRK00915
    Location:1 → 512
    PRK00915; 2-isopropylmalate synthase; Validated
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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