leuA 2-isopropylmalate synthase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Gene symbol: leuA
Gene description: 2-isopropylmalate synthase
Primary source: ASAP:ABE-0000267
Locus tag: b0074
See related: ECOCYC:EG11226
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0076
Summary: 2-isopropylmalate synthase (LeuA) carries out the first step in leucine biosynthesis. [More information is available at EcoCyc: EG11226].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

N-terminus verified by Edman degradation on mature peptide
Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 2-isopropylmalate synthase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables 2-isopropylmalate synthase activity	IEA Inferred from Electronic Annotation more info
enables 2-isopropylmalate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetyl-CoA C-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase, acyl groups converted into alkyl on transfer	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within branched-chain amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in leucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within leucine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leucine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leucine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_414616.1

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The following sections contain reference sequences that belong to a specific genome build. Explain