Format

Send to:

Choose Destination

leuA 2-isopropylmalate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947465, updated on 6-May-2021

Summary

Gene symbol
leuA
Gene description
2-isopropylmalate synthase
Primary source
ASAP:ABE-0000267
Locus tag
b0074
See related
ECOCYC:EG11226
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0076
Summary
2-isopropylmalate synthase (LeuA) carries out the first step in leucine biosynthesis. [More information is available at EcoCyc: EG11226].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Sequence:
NC_000913.3 (81958..83529, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-isopropylmalate dehydratase subunit LeuC Neighboring gene 3-isopropylmalate dehydrogenase Neighboring gene leu operon leader peptide Neighboring gene DNA-binding transcriptional dual regulator LeuO

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 2-isopropylmalate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 2-isopropylmalate synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables 2-isopropylmalate synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables acetyl-CoA C-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acyltransferase, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
2-isopropylmalate synthase
NP_414616.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    81958..83529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414616.1 2-isopropylmalate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414616.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P09151
    Conserved Domains (1) summary
    PRK00915
    Location:1512
    PRK00915; 2-isopropylmalate synthase; Validated
Support Center