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hemW heme chaperone HemW [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947446, updated on 30-Jul-2025
Official Symbol
hemW
Official Full Name
heme chaperone HemW
Primary source
ECOCYC:G7531
Locus tag
b2955
See related
ASAP:ABE-0009694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2950; yggW
Summary
YggW has three predicted Fe-binding iron-sulfur centers and seven predicted SAM binding sites. [More information is available at EcoGene: EG12983].
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Sequence:
NC_000913.3 (3097267..3098403)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PLP homeostasis protein Neighboring gene uncharacterized protein YggT Neighboring gene DUF167 domain-containing protein YggU Neighboring gene dITP/XTP pyrophosphatase Neighboring gene DUF1202 domain-containing protein YggM Neighboring gene L-asparaginase 2

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Transcriptional and proteomic analysis of a ferric uptake regulator (fur) mutant of Shewanella oneidensis: possible involvement of fur in energy metabolism, transcriptional regulation, and oxidative stress. Thompson DK, et al. Appl Environ Microbiol, 2002 Feb. PMID 11823232, Free PMC Article
  2. Regulon and promoter analysis of the E. coli heat-shock factor, sigma32, reveals a multifaceted cellular response to heat stress. Nonaka G, et al. Genes Dev, 2006 Jul 1. PMID 16818608, Free PMC Article
  3. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article
  4. The radical SAM protein HemW is a heme chaperone. Haskamp V, et al. J Biol Chem, 2018 Feb 16. PMID 29282292, Free PMC Article
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables coproporphyrinogen oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in porphyrin-containing compound biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in porphyrin-containing compound biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
heme chaperone HemW

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3097267..3098403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417430.1 heme chaperone HemW

    See identical proteins and their annotated locations for NP_417430.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A775TGG8
    Conserved Domains (1) summary
    PRK05660
    Location:1 → 378
    PRK05660; radical SAM family heme chaperone HemW
Nucleotide Protein
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