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dtpA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947436, updated on 11-Sep-2024

Summary

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Official Symbol
dtpA
Primary source
ECOCYC:G6877
Locus tag
b1634
See related
ASAP:ABE-0005469
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1630; tppB; ydgR
Summary
Overexpression increases di- and tri-peptide transport and confers hypersensitivity to alafosfalin (Weitz, 2006). [More information is available at EcoGene: EG13939]. The YdgR protein is a member of the POT family of peptide transporters . [More information is available at EcoCyc: G6877].
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Genomic context

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Sequence:
NC_000913.3 (1712769..1714271)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene SoxR [2Fe-2S] reducing system protein RsxG Neighboring gene SoxR [2Fe-2S] reducing system protein RsxE Neighboring gene endonuclease III Neighboring gene glutathione S-transferase GstA Neighboring gene pyridoxal kinase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells. Prabhala BK, et al. J Biol Chem, 2018 Jan 19. PMID 29150447, Free PMC Article
  2. Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Prabhala BK, et al. Res Microbiol, 2017 Jun. PMID 28214542
  3. Peptide transporter DtpA has two alternate conformations, one of which is promoted by inhibitor binding. Bippes CA, et al. Proc Natl Acad Sci U S A, 2013 Oct 15. PMID 24082128, Free PMC Article
  4. Functional and structural characterization of a prokaryotic peptide transporter with features similar to mammalian PEPT1. Weitz D, et al. J Biol Chem, 2007 Feb 2. PMID 17158458
  5. The number and nature of the peptide-transport systems of Escherichia coli: characterization of specific transport mutants. Alves RA, et al. Biochem Soc Trans, 1980 Dec. PMID 7007121

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells
    Title: The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells.
  2. findings show YdgR can transport 5 drugs. cCells not overexpressing YdgR were also able to transport these drugs in a proton-dependent oligopeptide transporter-like manner; orthologues of YdgR are found in several species in the gut microbiome; findings could have implications for further understanding the interaction of gut microbes and orally administered drugs
    Title: Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR.
  3. DtpB (YhiP) and DtpA (TppB, YdgR) are prototypical proton-dependent peptide transporters of Escherichia coli
    Title: DtpB (YhiP) and DtpA (TppB, YdgR) are prototypical proton-dependent peptide transporters of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables dipeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dipeptide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide:proton symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide:proton symporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tripeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tripeptide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables tripeptide transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in dipeptide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dipeptide transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dipeptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in oligopeptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in peptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in tripeptide transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tripeptide transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
dipeptide/tripeptide:H(+) symporter DtpA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1712769..1714271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416151.1 dipeptide/tripeptide:H(+) symporter DtpA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416151.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3P5DNZ8
    Conserved Domains (1) summary
    PRK09584
    Location:1 → 487
    tppB; dipeptide/tripeptide permease DtpA
Nucleotide Protein
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