hycI [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: hycI
Primary source: ECOCYC:G7414
Locus tag: b2717
See related: ASAP:ABE-0008931
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2712
Summary: FhlA regulon. [More information is available at EcoGene: EG13396]. HycI is a protease that cleaves the carboxy-terminus of HycE, modifying it into its final form as the large subunit of hydrogenase 3 . [More information is available at EcoCyc: G7414].
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NC_000913.3 Genomic Context describing neighboring genes

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Activation of a [NiFe]-hydrogenase-4 isoenzyme by maturation proteases.
Title: Activation of a [NiFe]-hydrogenase-4 isoenzyme by maturation proteases.
the crystal structure of HycI at 1.70 A resolution was presented.
Title: Crystal structure of hydrogenase maturating endopeptidase HycI from Escherichia coli.
N-terminus verified by Edman degradation on mature peptide
Title: Characterisation of a protease from Escherichia coli involved in hydrogenase maturation.
First solution structure of M52 family peptidase HycI is reported; the backbone dynamics is well correlated with the structural and functional basis of substrate recognition.
Title: Solution structure and backbone dynamics of an endopeptidase HycI from Escherichia coli: implications for mechanism of the [NiFe] hydrogenase maturation.

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Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain