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tktA transketolase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947420, updated on 3-Dec-2024

Summary

Official Symbol
tktA
Official Full Name
transketolase 1
Primary source
ECOCYC:EG11427
Locus tag
b2935
See related
ASAP:ABE-0009625
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2930; tkt
Summary
Mutations affect chromosomal supercoliing. [More information is available at EcoGene: EG11427]. TktA is responsible for the major transketolase activity in Escherichia coli, and TktB is responsible for the minor transketolase activity . [More information is available at EcoCyc: EG11427].
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Genomic context

Sequence:
NC_000913.3 (3079644..3081635, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene mannitol-specific PTS enzyme IICB component CmtA Neighboring gene mannitol-specific PTS enzyme IIA component CmtB Neighboring gene metalloprotease LoiP Neighboring gene agmatinase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thiamine pyrophosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transketolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transketolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transketolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in pentose-phosphate shunt IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within pentose-phosphate shunt, non-oxidative branch IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transketolase 1
YP_026188.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3079644..3081635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026188.1 transketolase 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026188.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1V2GNC3, A0A376RE42
    Conserved Domains (1) summary
    PRK12753
    Location:1663
    PRK12753; transketolase; Reviewed