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epd D-erythrose-4-phosphate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947413, updated on 25-Jun-2025
Official Symbol
epd
Official Full Name
D-erythrose-4-phosphate dehydrogenase
Primary source
ECOCYC:EG10368
Locus tag
b2927
See related
ASAP:ABE-0009607
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2923; gap2; gapB
Summary
The enzyme is composed of 4 monomers of 37.2 kDa each . [More information is available at EcoCyc: EG10368].
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Sequence:
NC_000913.3 (3072672..3073691, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fructose-bisphosphate aldolase class II Neighboring gene phosphoglycerate kinase Neighboring gene P-loop NTPase domain-containing protein YggC Neighboring gene fumarase E Neighboring gene fructose 1,6-bisphosphatase YggF Neighboring gene putative zinc-binding dehydrogenase YggP

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12. Yang Y, et al. J Bacteriol, 1998 Aug. PMID 9696782, Free PMC Article
  2. Characterization of Escherichia coli strains with gapA and gapB genes deleted. Seta FD, et al. J Bacteriol, 1997 Aug. PMID 9260967, Free PMC Article
  3. A naturally occurring horizontal gene transfer from a eukaryote to a prokaryote. Doolittle RF, et al. J Mol Evol, 1990 Nov. PMID 2124629
  4. Characterization of the molecular mechanisms involved in the differential production of erythrose-4-phosphate dehydrogenase, 3-phosphoglycerate kinase and class II fructose-1,6-bisphosphate aldolase in Escherichia coli. Bardey V, et al. Mol Microbiol, 2005 Sep. PMID 16102000
  5. The EIIGlc protein is involved in glucose-mediated activation of Escherichia coli gapA and gapB-pgk transcription. Charpentier B, et al. J Bacteriol, 1998 Dec. PMID 9851989, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis.
  2. epd translation initiation region and ORF are adapted in order to limit epd translation and to create an efficient RNase E entry site.
    Title: Characterization of the molecular mechanisms involved in the differential production of erythrose-4-phosphate dehydrogenase, 3-phosphoglycerate kinase and class II fructose-1,6-bisphosphate aldolase in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables erythrose-4-phosphate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within pyridoxal phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within pyridoxal phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pyridoxine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
D-erythrose-4-phosphate dehydrogenase
NP_417402.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3072672..3073691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417402.1 D-erythrose-4-phosphate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417402.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9QHG9
    Conserved Domains (1) summary
    PRK13535
    Location:2 → 334
    PRK13535; erythrose 4-phosphate dehydrogenase; Provisional
Nucleotide Protein
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