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pyrR DNA-binding transcriptional activator PyrR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947395, updated on 6-Jul-2026
Official Symbol
pyrR
Official Full Name
DNA-binding transcriptional activator PyrR
Primary source
ECOCYC:G7244
Locus tag
b2381
See related
ASAP:ABE-0007857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2377; ypdB
Summary
YpdAB may be a cognate two-component system sensor-regulator pair. [More information is available at EcoGene: EG14149]. A mutant containing a deletion of both ypdA and ypdB does not show a significant phenotype when measured by phenotype microarray . [More information is available at EcoCyc: G7244].
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Sequence:
NC_000913.3 (2500383..2501117)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutamate--pyruvate aminotransferase AlaC Neighboring gene sensor histidine kinase PyrS Neighboring gene putative AraC-type DNA-binding transcriptional regulator YpdC Neighboring gene putative PTS multiphosphoryl transfer protein FryA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Interspecific bacterial sensing through airborne signals modulates locomotion and drug resistance. Kim KS, et al. Nat Commun, 2013. PMID 23651997
  2. Regulatory roles of pyruvate-sensing two-component system PyrSR (YpdAB) in Escherichia coli K-12. Miyake Y, et al. FEMS Microbiol Lett, 2019 Jan 1. PMID 30624637
  3. A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance. Vilhena C, et al. J Bacteriol, 2018 Jan 1. PMID 29038258, Free PMC Article
  4. Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli. Hirakawa H, et al. J Bacteriol, 2003 Mar. PMID 12618449, Free PMC Article
  5. Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12. Oshima T, et al. Mol Microbiol, 2002 Oct. PMID 12366850

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. For induction of YpdAB function, the major exometabolite pyruvate in growing E. coli K-12 was identified as the inducer.
    Title: Regulatory roles of pyruvate-sensing two-component system PyrSR (YpdAB) in Escherichia coli K-12.
  2. findings suggest that the BtsS/BtsR and YpdA/YpdB network contributes to a balancing of the physiological state of all cells within a population
    Title: A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay response regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorelay response regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell motility EXP
Inferred from Experiment
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of single-species biofilm formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to antibiotic EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
DNA-binding transcriptional activator PyrR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2500383..2501117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416882.1 DNA-binding transcriptional activator PyrR

    See identical proteins and their annotated locations for NP_416882.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H2Z179
    Conserved Domains (1) summary
    COG3279
    Location:1 → 244
    LytT; DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version

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