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csgB curlin, minor subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947391, updated on 30-Jul-2025
Official Symbol
csgB
Official Full Name
curlin, minor subunit
Primary source
ECOCYC:G6547
Locus tag
b1041
See related
ASAP:ABE-0003534
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1027
Summary
The csgAB operon is regulated by CsgD. [More information is available at EcoGene: EG12621]. CsgB is the minor curlin subunit, which appears to function as a nucleator in the assembly of curli on the cell surface . [More information is available at EcoCyc: G6547].
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Sequence:
NC_000913.3 (1103951..1104406)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene curli assembly component CsgE Neighboring gene DNA-binding transcriptional dual regulator CsgD Neighboring gene curlin Neighboring gene curlin chaperone

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Nucleator function of CsgB for the assembly of adhesive surface organelles in Escherichia coli. Bian Z, et al. EMBO J, 1997 Oct 1. PMID 9312041, Free PMC Article
  2. Curli provide the template for understanding controlled amyloid propagation. Wang X, et al. Prion, 2008 Apr-Jun. PMID 19098444, Free PMC Article
  3. Curli fibers are required for development of biofilm architecture in Escherichia coli K-12 and enhance bacterial adherence to human uroepithelial cells. Kikuchi T, et al. Microbiol Immunol, 2005. PMID 16172544
  4. The curli nucleator protein, CsgB, contains an amyloidogenic domain that directs CsgA polymerization. Hammer ND, et al. Proc Natl Acad Sci U S A, 2007 Jul 24. PMID 17636121, Free PMC Article
  5. The molecular basis of functional bacterial amyloid polymerization and nucleation. Wang X, et al. J Biol Chem, 2008 Aug 1. PMID 18508760, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivation of the cysH gene results in increased surface adhesion and cell aggregation by activating the expression of the curli-encoding csgBAC operon via phosphoadenosine 59-phosphosulfate accumulation.
    Title: Sulfate assimilation pathway intermediate phosphoadenosine 59-phosphosulfate acts as a signal molecule affecting production of curli fibres in Escherichia coli.
  2. Constructed DeltatolC mutant and complement extraintestinal pathogenic E. coli (ExPEC) strains to study the role of TolC in the retention of biofilm formation and curli production capability under different osmotic conditions.
    Title: TolC promotes ExPEC biofilm formation and curli production in response to medium osmolarity.
  3. Substoichiometric concentrations of CsgB induce a change in the mechanism of CsgA aggregation from that of forming amorphous aggregates to that of structured intermediates similar to those of CsgB alone
    Title: The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism.
  4. fibrils formed by CsgA and CsgB, the primary curli proteins of Escherichia coli, possess many of the hallmarks typical of amyloid
    Title: The functional curli amyloid is not based on in-register parallel beta-sheet structure.
  5. CsgD overexpression can overcome temperature-dependent control of the curli-encoding csgBA operon, but not of the cellulose-related adrA gene
    Title: Cellulose modulates biofilm formation by counteracting curli-mediated colonization of solid surfaces in Escherichia coli.
  6. CsgB(trunc) was only able to act as a nucleator when cells were genetically manipulated to secrete higher concentrations of CsgA
    Title: The curli nucleator protein, CsgB, contains an amyloidogenic domain that directs CsgA polymerization.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within amyloid fibril formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amyloid fibril formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within curli assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of amyloid fibril formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of amyloid fibril formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pilus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pilus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
curlin, minor subunit

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1103951..1104406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415559.1 curlin, minor subunit

    See identical proteins and their annotated locations for NP_415559.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0ABK7
    Conserved Domains (1) summary
    PRK10101
    Location:1 → 151
    csgB; curlin minor subunit CsgB; Provisional
Nucleotide Protein
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