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gcvT aminomethyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947390, updated on 19-Nov-2025
Official Symbol
gcvT
Official Full Name
aminomethyltransferase
Primary source
ECOCYC:EG11442
Locus tag
b2905
See related
ASAP:ABE-0009536
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2900
Summary
Together with GcvH, GcvP and E3 (Lpd), GvcT forms a loosely associated complex known as the glycine cleavage system. [More information is available at EcoCyc: EG11442].
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Sequence:
NC_000913.3 (3049573..3050667, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycine decarboxylase Neighboring gene glycine cleavage system H protein Neighboring gene protein YqfI Neighboring gene 2-octaprenylphenol 6-hydroxylase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of the folate binding sites on the Escherichia coli T-protein of the glycine cleavage system. Okamura-Ikeda K, et al. J Biol Chem, 1999 Jun 18. PMID 10364177
  2. [Mapping of regulatory domain of T-protein from Escherichia coli]. Zhang H, et al. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2005 Mar. PMID 15812896
  3. Regulation of one-carbon biosynthesis and utilization in Escherichia coli. Meedel TH, et al. J Bacteriol, 1974 Jun. PMID 4598009, Free PMC Article
  4. Characterization of the gcv control region from Escherichia coli. Stauffer LT, et al. J Bacteriol, 1994 Oct. PMID 7928983, Free PMC Article
  5. The amino-terminal region of the Escherichia coli T-protein of the glycine cleavage system is essential for proper association with H-protein. Okamura-Ikeda K, et al. Eur J Biochem, 1999 Sep. PMID 10491090

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables aminomethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminomethyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aminomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine decarboxylation via glycine cleavage system IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine decarboxylation via glycine cleavage system NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in one-carbon metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of glycine cleavage complex IEA
Inferred from Electronic Annotation
more info
  
part_of glycine cleavage complex NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
aminomethyltransferase
NP_417381.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3049573..3050667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417381.1 aminomethyltransferase

    See identical proteins and their annotated locations for NP_417381.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9ASK1, A0A8S7EFZ2
    Conserved Domains (1) summary
    PRK00389
    Location:1 → 362
    gcvT; glycine cleavage system aminomethyltransferase GcvT
Nucleotide Protein
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