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betB betaine aldehyde dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947376, updated on 30-Jul-2025
Official Symbol
betB
Official Full Name
betaine aldehyde dehydrogenase
Primary source
ECOCYC:EG10110
Locus tag
b0312
See related
ASAP:ABE-0001072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0310
Summary
The bet genes are induced by choline, oxygen, and osmotic stress. [More information is available at EcoGene: EG10110].
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Sequence:
NC_000913.3 (327261..328733, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YkgH Neighboring gene choline dehydrogenase Neighboring gene DNA-binding transcriptional repressor BetI Neighboring gene choline:H(+) symporter

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Overproduction of spinach betaine aldehyde dehydrogenase in Escherichia coli. Structural and functional properties of wild-type, mutants and E. coli enzymes. Incharoensakdi A, et al. Eur J Biochem, 2000 Dec. PMID 11106411
  2. Induction of the L-arabinose operon. Schleif R. J Mol Biol, 1969 Nov 28. PMID 4902209
  3. Choline-glycine betaine pathway confers a high level of osmotic tolerance in Escherichia coli. Landfald B, et al. J Bacteriol, 1986 Mar. PMID 3512525, Free PMC Article
  4. Purification and characterization of osmoregulatory betaine aldehyde dehydrogenase of Escherichia coli. Falkenberg P, et al. Biochim Biophys Acta, 1990 Jun 20. PMID 2194570
  5. Characterization of an Escherichia coli gene encoding betaine aldehyde dehydrogenase (BADH): structural similarity to mammalian ALDHs and a plant BADH. Boyd LA, et al. Gene, 1991 Jul 15. PMID 1879697

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables aldehyde dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables betaine-aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables betaine-aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables betaine-aldehyde dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glycine betaine biosynthetic process from choline IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycine betaine biosynthetic process from choline IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
betaine aldehyde dehydrogenase
NP_414846.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    327261..328733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414846.1 betaine aldehyde dehydrogenase

    See identical proteins and their annotated locations for NP_414846.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8T6A167, A7LLT9
    Conserved Domains (1) summary
    PRK13252
    Location:1 → 490
    PRK13252; betaine aldehyde dehydrogenase; Provisional
Nucleotide Protein
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