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lplT lysophospholipid transporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947317, updated on 3-Dec-2024

Summary

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Official Symbol
lplT
Official Full Name
lysophospholipid transporter
Primary source
ECOCYC:EG12455
Locus tag
b2835
See related
ASAP:ABE-0009300
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2831; ygeD
Summary
Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG12455]. LplT is a major facilitator superfamily (MFS) protein that acts as a flippase for transbilayer movement of lysophospholipids. [More information is available at EcoCyc: EG12455].
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Genomic context

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Sequence:
NC_000913.3 (2972669..2973862, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF903 domain-containing lipoprotein YgdR Neighboring gene putative NADP(H)-dependent aldo-keto reductase Tas Neighboring gene fused 2-acylglycerophospho-ethanolamine acyltransferase/acyl-acyl carrier protein synthetase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli. Lin Y, et al. J Biol Chem, 2016 Jan 29. PMID 26613781, Free PMC Article
  2. Lysophospholipid flipping across the Escherichia coli inner membrane catalyzed by a transporter (LplT) belonging to the major facilitator superfamily. Harvat EM, et al. J Biol Chem, 2005 Mar 25. PMID 15661733
  3. Lysophospholipid remodeling mediated by the LplT and Aas protein complex in the bacterial envelope. Niu W, et al. J Biol Chem, 2024 Sep. PMID 39173951, Free PMC Article
  4. Sequence and function of the aas gene in Escherichia coli. Jackowski S, et al. J Biol Chem, 1994 Jan 28. PMID 8300626
  5. Microbial drug efflux proteins of the major facilitator superfamily. Saidijam M, et al. Curr Drug Targets, 2006 Jul. PMID 16842212

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lysophospholipid remodeling mediated by the LplT and Aas protein complex in the bacterial envelope.
    Title: Lysophospholipid remodeling mediated by the LplT and Aas protein complex in the bacterial envelope.
  2. lyso-PE and lysophosphatidylglycerol, but not lysophosphatidylcholine, are taken up by LplT for reacylation by acyltransferase/acyl-acyl carrier protein synthetase on the inner leaflet of the membrane
    Title: Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipid:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glycerophospholipid metabolic process EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within glycerophospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lysophospholipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid translocation EXP
Inferred from Experiment
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
lysophospholipid transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2972669..2973862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417312.1 lysophospholipid transporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417312.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAQ2RAB7
    Conserved Domains (1) summary
    PRK11195
    Location:12 → 397
    PRK11195; lysophospholipid transporter LplT; Provisional
Nucleotide Protein
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